Correlation Between Differentiation of Adrenocortical Zones and Telomere Lengths Measured by Q-FISH

التفاصيل البيبلوغرافية
العنوان: Correlation Between Differentiation of Adrenocortical Zones and Telomere Lengths Measured by Q-FISH
المؤلفون: Yuto Yamazaki, Keisuke Nonaka, Yoko Matsuda, Ja Mun Chong, Kaiyo Takubo, Naoshi Ishikawa, Tomio Arai, Hironobu Sasano, Junko Aida, Toshiyuki Ishiwata, Shoichiro Takakuma, Mototsune Kakizaki
المصدر: The Journal of Clinical Endocrinology & Metabolism. 104:5642-5650
بيانات النشر: The Endocrine Society, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Senescence, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, 030209 endocrinology & metabolism, Context (language use), Biology, Biochemistry, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Zona fasciculata, Internal medicine, medicine, Humans, Child, In Situ Hybridization, Fluorescence, Aged, Adrenal cortex, Biochemistry (medical), Infant, Newborn, Infant, Q-FISH, Middle Aged, Telomere, 030104 developmental biology, medicine.anatomical_structure, Zona glomerulosa, Child, Preschool, Adrenal Cortex, Female, Zona reticularis
الوصف: Context Adrenocortical zonation is associated with a markedly complex developmental process, and the pathogenesis and/or etiology of many disorders of adrenocortical zonal development have remained unknown. Cells from the three adrenocortical zones are morphologically and functionally differentiated, and the mature stage of cell development or senescence has been recently reported to be correlated with telomere length. However, the telomere length of each adrenocortical zonal cell has not yet been studied in human adrenal glands. Objective We aimed to study the telomere lengths of adrenocortical parenchymal cells from three different zones of the adrenal glands present during childhood, adolescence, and adulthood. Methods Adrenal glands of 30 autopsied subjects, aged between 0 and 68 years, were retrieved from pathology files. The normalized telomere to centromere ratio (NTCR), an index of telomere length, was determined in the parenchymal cells of the zona glomerulosa, zona fasciculata, and zona reticularis (ZR), using quantitative fluorescence in situ hybridization. Results NTCR of ZR cells was the longest, followed in decreasing order by that of zona glomerulosa and zona fasciculata cells in subjects aged 20 to 68 years, but no substantial differences in NTCR were detected among these three zones in the group Conclusion The telomere lengths for three zones in adrenal cortex were correlated with their differentiation in adulthood but not in childhood and adolescence.
تدمد: 1945-7197
0021-972X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201ae163b4f443c6954c35b2fc2c8632
https://doi.org/10.1210/jc.2019-00592
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....201ae163b4f443c6954c35b2fc2c8632
قاعدة البيانات: OpenAIRE