Utilizing dexamethasone intravitreal implant to control postoperative inflammation in refractory uveitis undergoing cataract surgery
| العنوان: | Utilizing dexamethasone intravitreal implant to control postoperative inflammation in refractory uveitis undergoing cataract surgery |
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| المؤلفون: | Xiao-Tong Yang, Xiaorong Li, Xue-Xue Cui, Xiaomin Zhang, Xinjun Ren, Bing Li, Yong-Tao Li |
| المصدر: | International Journal of Ophthalmology, Vol 14, Iss 2, Pp 317-322 (2021) Int J Ophthalmol |
| بيانات النشر: | Press of International Journal of Ophthalmology (IJO PRESS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Intraocular pressure, dexamethasone intravitreal implant (ozurdex), Visual acuity, genetic structures, medicine.medical_treatment, Intraocular lens, 03 medical and health sciences, 0302 clinical medicine, lcsh:Ophthalmology, intraocular lens implantation, Ophthalmology, medicine, Dexamethasone Intravitreal Implant, business.industry, Brief Report, Phacoemulsification, refractory uveitis, Cataract surgery, medicine.disease, eye diseases, lcsh:RE1-994, phacoemulsification, 030221 ophthalmology & optometry, Capsulotomy, sense organs, medicine.symptom, business, Uveitis |
| الوصف: | AIM: To report the effectiveness of intravitreal implantation of dexamethasone implant (Ozurdex) after phacoemulsification and intraocular lens implantation in refractory uveitis patients. METHODS: This single-center retrospective study conducted for refractory pan-uveitis patients who underwent cataract surgery combined with intravitreal Ozurdex implantation. The main outcome measurements were best-corrected visual acuity (BCVA), central retinal thickness (CRT), grade of anterior chamber cell (AAC), intraocular pressure (IOP), and systemic/ocular adverse events. RESULTS: Ten eyes of 7 patients were included. BCVA showed significant improvement at 1mo (P=0.004), 3mo (P=0.0004), and 6mo (P=0.001) post operation. There were no statistically significant differences in the postoperative CRT among follow-up groups (P>0.05). No significant differences were observed in the baseline IOP when compared to 1, 3, and 6mo (all P>0.05) post operation. One patient developed a transient elevated IOP post injection. Two eyes (20%) developed posterior capsular opacifications and underwent neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy. In six patients (8 eyes, 71.4%), the systemic steroid usage was reduced to below 10 mg/d. The patients experienced a mean of 1.4±0.52 recurrences of inflammation in the 6mo before operation and 0.7±0.48 in the 6mon post operation. The mean recurrence time was 13±0.58wk (range 12-14wk) post operation. In five of seven patients (7 out of 10 eyes), inflammation relapse was developed postoperatively. Only one patient (2 eyes) needed increased amounts of oral corticosteroids. Intraocular inflammation recurrence in the remaining patients was controlled by topical steroids. CONCLUSION: Ozurdex is considered a safe and effective approach to control postoperative inflammation in cataract surgery for patients with refractory uveitis in our study. After the disappearance of Ozurdex’s anti-inflammatory effects over time, in most cases the recurrent inflammation can be controlled by topical steroids. |
| اللغة: | English |
| تدمد: | 2227-4898 2222-3959 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20269952a88a575d092cab42ea27d562 http://ies.ijo.cn/en_publish/2021/2/20210221.pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....20269952a88a575d092cab42ea27d562 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22274898 22223959 |
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