Mediterranean diet supplemented with nuts reduces waist circumference and shifts lipoprotein subfractions to a less atherogenic pattern in subjects at high cardiovascular risk
| العنوان: | Mediterranean diet supplemented with nuts reduces waist circumference and shifts lipoprotein subfractions to a less atherogenic pattern in subjects at high cardiovascular risk |
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| المؤلفون: | Valentina Ruiz-Gutiérrez, Miguel-Angel Martínez-González, Ana Pérez-Heras, Fernando Arós, Dolores Corella, Montserrat Fitó, Emilio Ros, Nágila Raquel Teixeira Damasceno, Ramon Estruch, Montserrat Cofán, Aleix Sala-Vila |
| المساهمون: | Instituto de Salud Carlos III, Centro Nacional de Investigaciones Cardiovasculares (España), Generalitat de Catalunya |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname Digital.CSIC: Repositorio Institucional del CSIC Consejo Superior de Investigaciones Científicas (CSIC) |
| بيانات النشر: | Elsevier, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, PREDIMED, medicine.medical_specialty, Magnetic Resonance Spectroscopy, Time Factors, Waist, Mediterranean diet, Lipoproteins, Diet, Mediterranean, HDL size, Decreased LDL, LDL size, Cohort Studies, Risk Factors, Internal medicine, medicine, Humans, Plant Oils, Nuts, Increased ldl, Particle Size, Small-dense LDL, Triglycerides, Aged, Aged, 80 and over, VLDL size, business.industry, food and beverages, Cholesterol, LDL, Middle Aged, Atherosclerosis, Circumference, Predimed, Lipoproteins, LDL, Endocrinology, Cardiovascular Diseases, Female, lipids (amino acids, peptides, and proteins), Waist Circumference, Cardiology and Cardiovascular Medicine, business, Olive oil, Lipoprotein |
| الوصف: | [Objective]: The PREDIMED trial showed that Mediterranean diets supplemented with either extra-virgin olive oil or nuts reduced incident cardiovascular events compared to a control diet. Consumption of both supplemental foods has been associated with reduced LDL-cholesterol, but it is unknown whether they can shift lipoprotein subfractions to a less atherogenic pattern. We investigated changes in adiposity and lipoprotein subfractions after consumption of the PREDIMED diets. [Methods]: In a PREDIMED sub-cohort (n = 169), lipoprotein subclasses (particle concentrations and size) were determined by nuclear magnetic resonance spectroscopy at baseline and after intervention for 1 year. [Results]: Participants allocated to the Mediterranean diet supplemented with nuts showed significant reductions from baseline of waist circumference (mean [95% CI]; −5 cm [−7; −3]) and concentrations of medium-small (−27 nmol/l [−46; −8]) and very small LDL (−111 nmol/l [−180; −42]); decreased LDL particle number (a nuclear magnetic resonance-specific measurement) (−98 nmol/l [−184; −11]); and an increase of large LDL concentrations (54 nmol/l [18; 90]), with a net increase (0.2 nmol/l [0.1; 0.4]) of LDL size. The Mediterranean diets with olive oil and nuts increased large HDL concentrations (0.6 μM [0.0; 1.1] and 1.0 μM [0.4; 1.5], respectively). Compared to the other two intervention groups, participants in the nut-enriched diet showed significantly reduced waist circumference (p ≤ 0.006, both) and increased LDL size (p < 0.05, both). [Conclusion]: Lipoprotein subfractions are shifted to a less atherogenic pattern by consumption of Mediterranean diets enriched with nuts. The results contribute mechanistic evidence for the reduction of cardiovascular events observed in the PREDIMED trial. This study was funded in part by ISCIII (Spanish Ministry of Economy) through grants RTIC G03/140, RTIC RD 06/0045, and FIS PS09/01292 and grant CNIC 06/2007 from Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain. AS-V was supported by post-doctoral contract FIS CD07/0083. MF was supported by a joint contract of ISCIII and the Health Department of the Catalan Government (Generalitat de Catalunya), CP 06/00100. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206e5a5c7218fda953d463b9769e1455 http://hdl.handle.net/10261/247847 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....206e5a5c7218fda953d463b9769e1455 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |