Myotendinous Junction Components of Different Skeletal Muscles Present Morphological Changes in Obese Rats
| العنوان: | Myotendinous Junction Components of Different Skeletal Muscles Present Morphological Changes in Obese Rats |
|---|---|
| المؤلفون: | Lara Caetano Rocha, Ii-Sei Watanabe, Carolina Dos Santos Jacob, Jurandyr Pimentel Neto, Adriano Polican Ciena, Bruna Aléxia Cristofoletti Grillo, Giovana Zerbo Martinez |
| المساهمون: | Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP) |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | obesity, 0303 health sciences, extracellular matrix, Adipose tissue, Inflammation, Anatomy, Biology, Sarcomere, Tendon, Extracellular matrix, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, support collagen layer, medicine, Ultrastructure, myotendinous junction, sarcomere, Myotendinous junction, medicine.symptom, Muscle fibre, DIETA ANIMAL, Instrumentation, 030217 neurology & neurosurgery, 030304 developmental biology |
| الوصف: | Made available in DSpace on 2021-06-25T10:28:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Obesity is characterized by excess adipose tissue and chronic inflammation and promotes extensive changes that can compromise skeletal muscles' structural and functional integrity. Obesity can seriously impact the force transmission region between the muscle and the tendon, the myotendinous junction (MTJ). The present study aimed to investigate the plasticity of muscle fibers and MTJ regions in high-fat diet-induced obesity in rat tibialis anterior (TA) and soleus (SO) muscles. Wistar rats were divided into control and obese groups (induced by a high-fat diet). The samples of TA and SO muscles were prepared for histochemical and ultrastructural analysis (sarcomeres and MTJ projection). In the muscle fiber, similar adaptations were observed between the muscles of the smaller fiber (types I and IIa) in the obesity results. The MTJ region demonstrated different adaptations between the analyzed muscles. The TA-MTJ region has shorter ultrastructures, while in the SO-MTJ region, the ultrastructures were larger. We conclude that obesity induced by a high-fat diet promotes similar adaptation in the muscle fibers; however, in the MTJ region, the sarcoplasmatic projections and adjacent sarcomere demonstrate different adaptations according to distinct muscle phenotypes. Laboratory of Morphology and Physical Activity (LAMAF) Institute of Biosciences (IB) São Paulo State University (UNESP) Department of Anatomy Institute of Biomedical Sciences -ICB III University of São Paulo (USP) Laboratory of Morphology and Physical Activity (LAMAF) Institute of Biosciences (IB) São Paulo State University (UNESP) |
| تدمد: | 1435-8115 1431-9276 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2091b40ad7384bfd2fe1291716c5d51b https://doi.org/10.1017/s1431927621000313 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2091b40ad7384bfd2fe1291716c5d51b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14358115 14319276 |
|---|