FELLOW EYE CHANGES IN PATIENTS WITH NONISCHEMIC CENTRAL RETINAL VEIN OCCLUSION: Assessment of Perfused Foveal Microvascular Density and Identification of Nonperfused Capillaries
| العنوان: | FELLOW EYE CHANGES IN PATIENTS WITH NONISCHEMIC CENTRAL RETINAL VEIN OCCLUSION: Assessment of Perfused Foveal Microvascular Density and Identification of Nonperfused Capillaries |
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| المؤلفون: | Moataz M Razeen, Chun L Liu, Alfredo Dubra, Richard B Rosen, Alexander Pinhas, Nishit Shah, Rishard Weitz, Toco Yuen Ping Chui, Eric Cheang, Yusufu N. Sulai, Michael Dubow, Alexander Gan |
| المساهمون: | Institut de génétique et microbiologie [Orsay] (IGM), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Retina (Philadelphia, Pa.) Retina (Philadelphia, Pa.), 2015, 35 (10), pp.2028-36. ⟨10.1097/IAE.0000000000000586⟩ |
| بيانات النشر: | HAL CCSD, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, genetic structures, [SDV]Life Sciences [q-bio], Article, Functional Laterality, chemistry.chemical_compound, Young Adult, Optical coherence tomography, Central retinal vein occlusion, Foveal, Ischemia, Ophthalmology, Occlusion, Retinal Vein Occlusion, Medicine, Humans, Fluorescein, Fluorescein Angiography, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Microvascular Density, Retinal Vessels, General Medicine, Middle Aged, medicine.disease, Fluorescein angiography, eye diseases, 3. Good health, Capillaries, chemistry, Regional Blood Flow, Visual Field Tests, Female, sense organs, Visual Fields, business, Microperimetry, Tomography, Optical Coherence |
| الوصف: | Purpose Eyes fellow to nonischemic central retinal vein occlusion (CRVO) were examined for abnormalities, which might explain their increased risk for future occlusion, using adaptive optics scanning light ophthalmoscope fluorescein angiography. Methods Adaptive optics scanning light ophthalmoscope fluorescein angiography foveal microvascular densities were calculated. Nonperfused capillaries adjacent to the foveal avascular zone were identified. Spectral domain optical coherence tomography, ultrawide field fluorescein angiographies, and microperimetry were also performed. Results Ten fellow eyes of nine nonischemic CRVO and 1 nonischemic hemi-CRVO subjects and four affected eyes of three nonischemic CRVO and one nonischemic hemi-CRVO subjects were imaged. Ninety percent of fellow eyes and 100% of affected eyes demonstrated at least 1 nonperfused capillary compared with 31% of healthy eyes. Fellow eye microvascular density (35 ± 3.6 mm(-1)) was significantly higher than that of affected eyes (25 ± 5.2 mm(-1)) and significantly lower than that of healthy eyes (42 ± 4.2 mm(-1)). Compared with healthy controls, spectral domain optical coherence tomography thicknesses showed no significant difference, whereas microperimetry and 2/9 ultrawide field fluorescein angiography revealed abnormalities in fellow eyes. Conclusion Fellow eye changes detectable on adaptive optics scanning light ophthalmoscope fluorescein angiography reflect subclinical pathology difficult to detect using conventional imaging technologies. These changes may help elucidate the pathogenesis of nonischemic CRVO and help identify eyes at increased risk of future occlusion. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2094e31ef76aa8c1bcfb9f19a2bc61f2 https://hal.archives-ouvertes.fr/hal-01433090 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2094e31ef76aa8c1bcfb9f19a2bc61f2 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |