Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease
| العنوان: | Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease |
|---|---|
| المؤلفون: | Frank J. Gunn-Moore, Wanjia Yu, Doris Chen, Laura Aitken |
| المصدر: | Cells, Vol 10, Iss 3024, p 3024 (2021) Cells |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Nervous system, QH301-705.5, Regulator, Down-Regulation, Review, Biology, Pathogenesis, Willin/FRMD6, Alzheimer Disease, medicine, Humans, oxidative stress, Mechanotransduction, Biology (General), mechanotransduction, Neurons, Hippo signaling, Neurodegeneration, neurodegeneration, Membrane Proteins, General Medicine, medicine.disease, Actin cytoskeleton, Phenotype, medicine.anatomical_structure, Neuroscience, Alzheimer’s disease, Protein Binding, Signal Transduction |
| الوصف: | The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton dynamics and mechanical phenotype of neuronal cells through ERK signaling. Physiological functions of Willin/FRMD6 in the nervous system include neuronal differentiation, myelination, nerve injury repair, and vesicle exocytosis. The newly established neuronal role of Willin/FRMD6 is of particular interest given the mounting evidence suggesting a role for Willin/FRMD6 in Alzheimer’s disease (AD), including a series of genome wide association studies that position Willin/FRMD6 as a novel AD risk gene. Here we describe recent findings regarding the role of Willin/FRMD6 in the nervous system and its actions in cellular perturbations related to the pathogenesis of AD. |
| اللغة: | English |
| تدمد: | 2073-4409 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ac0bcf7bfac2c0df9f22dee4f17104 https://www.mdpi.com/2073-4409/10/11/3024 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....20ac0bcf7bfac2c0df9f22dee4f17104 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
|---|