DPPA2, DPPA4, and other DPPA factor epigenomic functions in cell fate and cancer
| العنوان: | DPPA2, DPPA4, and other DPPA factor epigenomic functions in cell fate and cancer |
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| المؤلفون: | Paul S. Knoepfler, Rachel Herndon Klein |
| المصدر: | Stem Cell Reports |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Epigenomics, Pluripotent Stem Cells, Pluripotency, cancer stem cells, Review, Biology, Biochemistry, Cancer stem cell, Neoplasms, Zygotic Gene Activation, Genetics, Animals, Humans, Cell Lineage, Induced pluripotent stem cell, Cell Differentiation, Genomics, Cell Biology, Cell biology, Chromatin, Cancer cell, Epigenetics, Stem cell, DPPA2, Transcription, Reprogramming, Transcription Factors, DPPA4, Developmental Biology, Bivalent chromatin |
| الوصف: | Summary Many gene networks are shared between pluripotent stem cells and cancer; a concept exemplified by several DPPA factors such as DPPA2 and DPPA4, which are highly and selectively expressed in stem cells but also found to be reactivated in cancer. Despite their striking expression pattern, for many years the function of DPPA2 and DPPA4 remained a mystery; knockout of Dppa2 and Dppa4 did not affect pluripotency, but caused lung and skeletal defects late in development, long after Dppa2 and Dppa4 expression had been turned off. A number of recent papers have further clarified and defined the roles of these important factors, identifying roles in priming the chromatin and maintaining developmental competency through regulating both H3K4me3 and H3K27me3 at bivalent chromatin domains, and acting to remodel chromatin and facilitate reprogramming of somatic cells to induced pluripotency. These findings highlight an important regulatory role for DPPA2 and DPPA4 at the transitional boundary between pluripotency and differentiation and may have relevance to the functions of DPPA2 and 4 in the context of cancer cells as well. In this review, R. Klein and P. Knoepfler summarize the roles of DPPA family members in both pluripotency and oncogenesis, highlighting the connection between these two cellular states. They describe the functions of DPPA factors in priming the chromatin and acting at the boundary between pluripotency and differentiation. |
| تدمد: | 2213-6711 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ce6fffa9108ff3f372b8be4843b3f0 https://doi.org/10.1016/j.stemcr.2021.10.008 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....20ce6fffa9108ff3f372b8be4843b3f0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22136711 |
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