Causes and consequences of RNA polymerase II stalling during transcript elongation
| العنوان: | Causes and consequences of RNA polymerase II stalling during transcript elongation |
|---|---|
| المؤلفون: | Jesper Q. Svejstrup, Daniel Blears, Melvin Noe Gonzalez |
| المصدر: | Noe Gonzalez, M, Blears, D & Svejstrup, J Q 2021, ' Causes and consequences of RNA polymerase II stalling during transcript elongation ', Nature Reviews Molecular Cell Biology, vol. 22, pp. 3-21 . https://doi.org/10.1038/s41580-020-00308-8 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Genome instability, 0303 health sciences, DNA damage, RNA, RNA polymerase II, Cell Biology, Biology, Cell biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, biology.protein, RNA Cleavage, Molecular Biology, Gene, 030217 neurology & neurosurgery, DNA, Polymerase, 030304 developmental biology |
| الوصف: | The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory barriers, such as promoter-proximal pausing, nucleosomes, RNA secondary structures and the underlying DNA sequence. More substantial blocking of Pol II translocation can be caused by other physiological circumstances and extrinsic obstacles, including other transcribing polymerases, the replication machinery and several types of DNA damage, such as bulky lesions and DNA double-strand breaks. Although numerous different obstacles cause Pol II stalling or arrest, the cell somehow distinguishes between them and invokes different mechanisms to resolve each roadblock. Resolution of Pol II blocking can be as straightforward as temporary backtracking and transcription elongation factor S-II (TFIIS)-dependent RNA cleavage, or as drastic as premature transcription termination or degradation of polyubiquitylated Pol II and its associated nascent RNA. In this Review, we discuss the current knowledge of how these different Pol II stalling contexts are distinguished by the cell, how they overlap with each other, how they are resolved and how, when unresolved, they can cause genome instability. |
| وصف الملف: | application/pdf |
| تدمد: | 1471-0080 1471-0072 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214a11d9e645599f94bdc5a94355aade https://doi.org/10.1038/s41580-020-00308-8 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....214a11d9e645599f94bdc5a94355aade |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14710080 14710072 |
|---|