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Nitroprusside single-dose prevents the psychosis-like behavior induced by ketamine in rats for up to one week

التفاصيل البيبلوغرافية
العنوان: Nitroprusside single-dose prevents the psychosis-like behavior induced by ketamine in rats for up to one week
المؤلفون: Jaime Eduardo Cecílio Hallak, Bruno Lobão-Soares, Glen B. Baker, Vanessa de Paula Soares, Thais Ramalho, Leslie Teixeira, Serdar M. Dursun, Elaine C. Gavioli, João Paulo Maia-de-Oliveira
المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
بيانات النشر: Elsevier BV, 2015.
سنة النشر: 2015
مصطلحات موضوعية: Male, Nitroprusside, Psychosis, Time Factors, Rotation, medicine.medical_treatment, Video Recording, Motor Activity, Pharmacology, Open field, Random Allocation, Stereotypy, medicine, Animals, SNP, Nitric Oxide Donors, Ketamine, Rats, Wistar, Antipsychotic, ANTIPSICÓTICOS, Saline, Biological Psychiatry, business.industry, medicine.disease, Disease Models, Animal, Psychiatry and Mental health, Treatment Outcome, Psychotic Disorders, Anesthesia, Sodium nitroprusside, Stereotyped Behavior, medicine.symptom, business, Software, Antipsychotic Agents, medicine.drug
الوصف: Recently, we found a rapid and long-lasting improvement of symptoms in schizophrenic patients on antipsychotics after a single four-hour infusion of sodium nitroprusside (SNP), a nitric oxide (NO) donor with a short half-life. This improvement persisted for up to 4 weeks. Because these patients remained on antipsychotics after infusion of SNP was finished, the question arises about whether this improvement was due to SNP itself. We have now investigated whether SNP, alone, can produce preventive antipsychotic effects in rats treated with ketamine (KET). 56 adult rats divided into 7 groups were infused with SNP 4 mg/kg, KET 25 mg/kg, or saline as follows: group1 — saline, group2 — SNP, group3 — KET, group4 — KET 12 h after SNP, group5 — KET 1 day after SNP, group6 — KET 2 days after SNP, and group7 — KET 1 week after SNP. The animals were filmed in an open field arena for 30 min and the videos were later analyzed by ANY-Maze software to measure activity and stereotypy. SNP significantly prevented the emergence of hyperactivity induced by KET when it was administered for up to 1 week before KET, and prevented the emergence of stereotypies when it was administered for up to 1 day before KET. These findings in rats, which have an even faster metabolic rate than humans, suggest that the long-lasting effects observed in our clinical trial with SNP in humans could have been due to SNP itself, and indicate for the first time that SNP may present preventive antipsychotic effects.
تدمد: 0920-9964
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2168f3b7ca751720a3efc3b2ef4aa6ad
https://doi.org/10.1016/j.schres.2014.12.035
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....2168f3b7ca751720a3efc3b2ef4aa6ad
قاعدة البيانات: OpenAIRE
الوصف
تدمد:09209964