This study aimed to report the magnitude of modifiable lifestyle factors, their relationships with metabolic disorders in Burkinabè adults by using nationally representative data. This cross-sectional study included 4100 adults selected through multistage cluster sampling performed during the first national survey conducted in 2013 in Burkina Faso. The modifiable factors we considered were tooth cleaning, fruit and/or vegetable (FV) intake, substances’ use, physical activity and overweight/obesity, while metabolic syndrome abnormal components defined metabolic disorders. We performed logistic regressions. 31.1% cleaned the teeth at least twice a day, 14.7% consumed five or more FV, 39.7% used alcohol and/or tobacco, the prevalence of physical inactivity and overweight/obesity was respectively 6.6% and 17.7%. About 41.0% had at least two metabolic disorders and 9.5% had at least three. Lifestyle factors associated with having at least two metabolic disorders were overweight/obesity, more FV intake (when five or more aOR=1.5, p