Rapid Spread in Japan of Unusual G9P[8] Human Rotavirus Strains Possessing NSP4 Genes of E2 Genotype
| العنوان: | Rapid Spread in Japan of Unusual G9P[8] Human Rotavirus Strains Possessing NSP4 Genes of E2 Genotype |
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| المؤلفون: | Saori, Fukuda, Yuki, Akari, Riona, Hatazawa, Manami, Negoro, Takaaki, Tanaka, Kazutoyo, Asada, Haruna, Nakamura, Katsumi, Sugiura, Masakazu, Umemoto, Haruo, Kuroki, Hiroaki, Ito, Shigeki, Tanaka, Mitsue, Ito, Tomihiko, Ide, Takayuki, Murata, Kiyosu, Taniguchi, Shigeru, Suga, Hajime, Kamiya, Takashi, Nakano, Koki, Taniguchi, Satoshi, Komoto |
| المصدر: | Japanese Journal of Infectious Diseases. 75:466-475 |
| بيانات النشر: | Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Rotavirus, Microbiology (medical), Infectious Diseases, Genotype, Japan, Humans, Genome, Viral, General Medicine, Child, Phylogeny, Rotavirus Infections |
| الوصف: | The emergence of unusual G9P[8]-E2 human rotaviruses in the Tokyo metropolitan area, Japan, in 2018 has been reported. During rotavirus strain surveillance in different regions of Japan (Mie, Okayama, and Chiba prefectures), G9P[8]-E2 strains were detected in children with diarrhea from all three prefectures. Here, we characterized the whole genome of seven representative G9P[8]-E2 strains. In the full-genome-based analysis, the seven study strains exhibited a unique genotype configuration with the NSP4 gene of genogroup 2 in a genogroup 1 genomic backbone: G9-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1. This genotype constellation was shared by the Tokyo G9P[8]-E2 strains. Phylogenetic analysis showed that all 11 genes, except NSP4, of the seven study strains appeared to have originated from co-circulating Wa-like G9P[8]-E1 strains. In contrast, NSP4 appeared to have originated from the co-circulating DS-1-like G2P[4]-E2 strains. Thus, G9P[8]-E2 strains appear to be derived through reassortment between G9P[8]-E1 and G2P[4]-E2 strains in Japan. Notably, the seven study G9P[8]-E2 strains and Tokyo G9P[8]-E2 strains were revealed to have 11-segment genomes almost indistinguishable from one another in their sequences (99.3-100%), indicating all these G9P[8]-E2 strains had a common origin. To our knowledge, this is the first description of the rapid spread of G9P[8]-E2 strains across a country. |
| تدمد: | 1884-2836 1344-6304 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21dfda1c4d4a36c29e07563c891a2692 https://doi.org/10.7883/yoken.jjid.2022.020 |
| رقم الأكسشن: | edsair.doi.dedup.....21dfda1c4d4a36c29e07563c891a2692 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18842836 13446304 |
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