Microbiome Study of Initial Gut Microbiota from Newborn Infants to Children Reveals that Diet Determines Its Compositional Development
| العنوان: | Microbiome Study of Initial Gut Microbiota from Newborn Infants to Children Reveals that Diet Determines Its Compositional Development |
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| المؤلفون: | Ju-Hoon Lee, You-Tae Kim, Hye-Jin Ku |
| المصدر: | Journal of Microbiology and Biotechnology. 30:1067-1071 |
| بيانات النشر: | Korean Society for Microbiology and Biotechnology, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0106 biological sciences, Serratia, Physiology, Gut flora, digestive system, 01 natural sciences, Applied Microbiology and Biotechnology, Feces, fluids and secretions, Klebsiella, 010608 biotechnology, Humans, Weaning, Microbiome, Toddler, Diet type, Bifidobacterium, Milk, Human, biology, Breast milk intake, Infant, Newborn, Infant, General Medicine, biology.organism_classification, Diet, Gastrointestinal Microbiome, Breast Feeding, Child, Preschool, Female, sense organs, Biotechnology |
| الوصف: | To understand the formation of initial gut microbiota, three initial fecal samples were collected from two groups of two breast milk-fed (BM1) and seven formula milk-fed (FM1) infants, and the compositional changes in gut microbiota were determined using metagenomics. Compositional change analysis during week one showed that Bifidobacterium increased from the first to the third fecal samples in the BM1 group (1.3% to 35.1%), while Klebsiella and Serratia were detected in the third fecal sample of the FM1 group (4.4% and 34.2%, respectively), suggesting the beneficial effect of breast milk intake. To further understand the compositional changes during progression from infancy to childhood (i.e., from three weeks to five years of age), additional fecal samples were collected from four groups of two breast milk-fed infants (BM2), one formula milk-fed toddler (FM2), three weaning food-fed toddlers (WF), and three solid food-fed children (SF). Subsequent compositional change analysis and principal coordinates analysis (PCoA) revealed that the composition of the gut microbiota changed from an infant-like composition to an adult-like one in conjunction with dietary changes. Interestingly, overall gut microbiota composition analyses during the period of progression from infancy to childhood suggested increasing complexity of gut microbiota as well as emergence of a new species of bacteria capable of digesting complex carbohydrates in WF and SF groups, substantiating that diet type is a key factor in determining the composition of gut microbiota. Consequently, this study may be useful as a guide to understanding the development of initial gut microbiota based on diet. |
| تدمد: | 1738-8872 1017-7825 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e1ecb18e0386ac7a15aa84144eb01a https://doi.org/10.4014/jmb.2002.02042 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....21e1ecb18e0386ac7a15aa84144eb01a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17388872 10177825 |
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