Metabolomics approach revealed robust changes in amino acid and biogenic amine signatures in patients with schizophrenia in the early course of the disease
| العنوان: | Metabolomics approach revealed robust changes in amino acid and biogenic amine signatures in patients with schizophrenia in the early course of the disease |
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| المؤلفون: | Liisa Leppik, Madis Parksepp, Kadri Koch, Kärt Uppin, Eero Vasar, Mihkel Zilmer, Raul Kangro, Liina Haring |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Biogenic Amines, Psychosis, Taurine, Proline, Glutamine, Science, medicine.medical_treatment, Glutamic Acid, Pharmacology, Article, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tandem Mass Spectrometry, Biogenic amine, medicine, Humans, Metabolomics, Amino Acids, Antipsychotic, chemistry.chemical_classification, Aspartic Acid, Multidisciplinary, Methionine, Molecular medicine, Ornithine, medicine.disease, Amino acid, Early Diagnosis, 030104 developmental biology, chemistry, Metabolome, Schizophrenia, Medicine, Female, Asparagine, Biomarkers, 030217 neurology & neurosurgery, Antipsychotic Agents, Chromatography, Liquid, Neuroscience |
| الوصف: | The primary objective of this study was to evaluate how schizophrenia (SCH) spectrum disorders and applied antipsychotic (AP) treatment affect serum level of amino acids (AAs) and biogenic amines (BAs) in the early course of the disorder. We measured 21 different AAs and 10 BAs in a sample of antipsychotic (AP)-naïve first-episode psychosis (FEP) patients (n = 52) at baseline, after 0.6-year as well as after 5.1-year treatment compared to control subjects (CSs, n = 37). Serum levels of metabolites were determined with AbsoluteIDQ p180 kit using flow injection analysis tandem mass spectrometry and liquid chromatography technique. Elevated level of taurine and reduced level of proline and alpha-aminoadipic acid (alpha-AAA) were established as metabolites with significant change in AP-naïve FEP patients compared to CSs. The following 0.6-year treatment restored these alterations. However, further continuous 5.1-year AP treatment changed the metabolic profile substantially. Significantly elevated levels of asparagine, glutamine, methionine, ornithine and taurine, alongside with decreased levels of aspartate, glutamate and alpha-AAA were observed in the patient group compared to CSs. These biomolecule profile alterations provide further insights into the pathophysiology of SCH spectrum disorders and broaden our understanding of the impact of AP treatment in the early stages of the disease. |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e4c8cef4271925ee00d18e0a012668 https://doi.org/10.1038/s41598-020-71014-w |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....21e4c8cef4271925ee00d18e0a012668 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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