Protective effects of Celosia argentea Linn. Vitamin E and dexamethasone on radiation-induced damage on the developing rat cerebellum
| العنوان: | Protective effects of Celosia argentea Linn. Vitamin E and dexamethasone on radiation-induced damage on the developing rat cerebellum |
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| المؤلفون: | I. O. Imosemi, Adelofolarin Obanishola Malomo, Love Chioma Kanu, Olatunde Owoeye |
| المصدر: | Anatomy Journal of Africa; Vol 8, No 2 (2019); 1647-1661 |
| بيانات النشر: | African Journals Online (AJOL), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, medicine.medical_specialty, Antioxidant, medicine.medical_treatment, medicine.disease_cause, Gamma-radiation, neuroprotective, plant products, rat brain, Neuroprotection, 050105 experimental psychology, 03 medical and health sciences, Cresyl violet, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Medicine, 0501 psychology and cognitive sciences, Pediatrics, Perinatology, and Child Health, Dexamethasone, business.industry, Vitamin E, 05 social sciences, Histology, Endocrinology, chemistry, Gestation, business, 030217 neurology & neurosurgery, Oxidative stress, medicine.drug |
| الوصف: | The potential neuroprotective effect of aqueous extract of Celosia argentea Linn (AECA), Vitamin E (Vit E) and Dexamethasone (Dexa) on radiation-induced damage on the developing rat cerebellum was studied. Forty-two female rats weighing between 147 g and 222 g were randomized into six groups (N=7). Control group – Group I, Irrad group – Group II, AECA group – Group III, AECA + Irrad group – Group IV, Vit E + Irrad group – Group V and Dexa+ Irrad group – Group VI. Rats were mated and pregnant rats were exposed to 2.5 Gy gamma radiation on gestation day 7. The administration of 400 mg/kg of AECA, 500 mg/kg of Vit E and 0.005 ml/rat of Dexa started from gestation day 1 till postnatal day 28. Postpartum, 5 pups from each group were exposed to behavioural and biochemical tests and then sacrificed. Brain tissue fixed in 10% formalin, processed by paraffin wax method was stained with H&E and Cresyl violet stains for histology. Radiation significantly (p |
| وصف الملف: | application/pdf |
| تدمد: | 2305-9478 2226-6054 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ee1c7443d3c6e975075052c65e33cd https://doi.org/10.4314/aja.v8i2.190407 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....21ee1c7443d3c6e975075052c65e33cd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23059478 22266054 |
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