Fisetin inhibits pristine-induced systemic lupus erythematosus in a murine model through CXCLs regulation
| العنوان: | Fisetin inhibits pristine-induced systemic lupus erythematosus in a murine model through CXCLs regulation |
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| المؤلفون: | Su‑Ping Xu, Yong‑Sheng Li |
| المصدر: | International Journal of Molecular Medicine |
| بيانات النشر: | Spandidos Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Chemokine, Flavonols, fisetin, Chemokine CXCL1, Blotting, Western, Chemokine CXCL2, Interleukin-1beta, Lupus nephritis, medicine.disease_cause, Proinflammatory cytokine, Autoimmunity, Mice, 03 medical and health sciences, chemistry.chemical_compound, systemic lupus erythematosus, Genetics, Animals, Lupus Erythematosus, Systemic, Medicine, lupus nephritis, Flavonoids, Lupus erythematosus, biology, Interleukin-6, Terpenes, Tumor Necrosis Factor-alpha, business.industry, Cell Differentiation, Articles, General Medicine, CXCLs, Flow Cytometry, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, RAW 264.7 Cells, 030104 developmental biology, Th17 differentiation, chemistry, biology.protein, Cancer research, Th17 Cells, Female, Tumor necrosis factor alpha, business, Fisetin, Small nuclear ribonucleoprotein |
| الوصف: | Systemic lupus erythematosus (SLE) is associated with an increased risk of vascular complications. Lupus nephritis is a major manifestation of SLE in the clinic. Lupus nephritis is elevated by T helper type 17 (Th17) cells, the major pro‑inflammatory T‑cell subset, leading to autoimmunity modulation. Therapeutic treatments targeting leukocyte recruitment may be useful in attenuating vascular complications linked to SLE progression. 3,7,3',4'‑Tetrahydroxyflavone (fisetin) is a flavonol and a member of the flavonoid polyphenols. It is present in various fruits and vegetables, including persimmons, apples, kiwis, grapes, onions, strawberries and cucumbers. In the present study, the effects of fisetin against SLE induced by pristane (PRI) were evaluated in mice. Fisetin was indicated to reduce PRI‑induced anti‑double stranded DNA, anti‑ small nuclear ribonucleoprotein and the ratio of albumin to creatinine in urine. In addition, the chemokine (C‑X‑C motif) ligand (CXCL) signaling pathway was activated for PRI treatment, which was reversed by fisetin administration by reducing CXCL‑1 and 2, chemokine (C‑C motif) ligand 3, as well as CXC receptor 2 expression. In addition, the induction of inflammatory cytokines, including interleukin (IL)‑6, tumor necrosis factor‑α, IL‑1β, as well as the chemokine interferon‑γ, by PRI were downregulated by fisetin treatment in mice. Furthermore, Th17 cells and their associated cytokines were highly induced by PRI treatment, which was inhibited by fisetin administration. The present results indicated that fisetin may be an effective management for SLE by targeting the CXCL signaling pathway and regulating Th17 differentiation during lupus nephritis development. |
| تدمد: | 1791-244X 1107-3756 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21fedfc97423677dcef9f7aac11fe6dc https://doi.org/10.3892/ijmm.2018.3903 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....21fedfc97423677dcef9f7aac11fe6dc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1791244X 11073756 |
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