Additional file 1 : Online supplementary Table S1. Baseline patient- and disease- characteristics at the start of the second TNFi in the entire population. Online supplementary Table S2. Baseline patient- and disease- characteristics at the start of the second TNFi in the entire population and per reason of discontinuation of the first TNFi. Online Supplementary Table S3. Association between the reason for discontinuation of the first TNFi and response to the second TNFi (with alternative definition of secondary failure to first TNFi).