Low-frequency (20 kHz) ultrasonic modulation of drug action
| العنوان: | Low-frequency (20 kHz) ultrasonic modulation of drug action |
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| المؤلفون: | Algimantas Bubulis, Augusta Volkevičiūtė, Vytis Bajoriūnas, Edgaras Stankevičius, Agilė Tunaitytė, Mantas Venslauskas, Silvijus Abramavicius |
| المساهمون: | „Elsevier Science' grupė |
| المصدر: | Ultrasound in medicine & biology, New York : Elsevier, 2020, vol. 46, iss. 11, p. 3017-3031 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Agonist, Acoustics and Ultrasonics, Fenoldopam, medicine.drug_class, Biophysics, TRPV1, Pharmacology, Pulmonary Artery, Glibenclamide, 03 medical and health sciences, 0302 clinical medicine, Low-frequency ultrasound, medicine, Animals, Humans, Radiology, Nuclear Medicine and imaging, Mesentery, Rats, Wistar, Mesenteric arteries, Insonation, Ultrasonic modulation, Radiological and Ultrasound Technology, Electrical impedance myography, Calcium signaling, Drug action, Chemistry, Myography, Potassium channel, Rats, 030104 developmental biology, medicine.anatomical_structure, Ultrasonic Waves, medicine.symptom, 030217 neurology & neurosurgery, Vasoconstriction, medicine.drug |
| الوصف: | We tested the effect of low-frequency ultrasound (LUS, 20 kHz, 4 W/cm2) on the function of rat mesentery and human pulmonary arteries with wire myography. The vessels were induced to contract with either noradrenaline or physiologic saline solution (PSS) with a high potassium concentration (KPSS) and then incubated with capsaicin (2.1 × 10–7 M, TRPV1 [transient receptor potential vanilloid 1] activator), dopamine (1 × 10–4 M, dopamine and α2-receptor activator), or fenoldopam (dopamineA1 receptor agonist, 1 × 10–4 M) with and without glibenclamide (1 μM, KATP [adenosine triphosphate {sensitive potassium channel (ATP)}-sensitive potassium channel] inhibitor and α2-receptor modulator), and insonated. Vessels were incubated in Ca2+-free PSS and induced to contract with added extracellular Ca2+ and noradrenaline. Pulmonary arteries were induced to contract with KPSS and dopamine. Then the vessels were insonated. LUS inhibited the influx of external Ca2+, inhibited the dopamine-induced vasoconstriction in the KPSS (glibenclamide reversible), reduced the capsaicin-induced vasorelaxation, increased the gentamicin-induced vasorelaxation and increased the dopamine-induced contraction in the KPSS in human pulmonary arteries. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0301-5629 1879-291X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220feda1d3e6f9414b4fe11392125d3a https://vb.ktu.edu/KTU:ELABAPDB67704653&prefLang=en_US |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....220feda1d3e6f9414b4fe11392125d3a |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 03015629 1879291X |
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