The Stability of A1,B29-Adipoylinsulin to Chemical and Enzymatic Degradation
| العنوان: | The Stability of A1,B29-Adipoylinsulin to Chemical and Enzymatic Degradation |
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| المؤلفون: | Klaus Lübke, Stephen M. L. Robinson |
| المصدر: | Biological Chemistry. 359:225-230 |
| بيانات النشر: | Walter de Gruyter GmbH, 1978. |
| سنة النشر: | 1978 |
| مصطلحات موضوعية: | Partial hydrolysis, medicine.medical_treatment, Clinical Biochemistry, Biochemistry, chemistry.chemical_compound, Cytosol, Drug Stability, medicine, Animals, Chymotrypsin, Insulin, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Hydrolysis, Rats, Enzyme, biology.protein, Degradation (geology), Cattle, Derivative (chemistry), Enzymatic degradation |
| الوصف: | The degradation of A1,B29-adipolyinsulin by partial hydrolysis, by disulphide-bond exchange, by chymotrypsin and by a cytosolic enzyme fraction of rat liver was measured and compared with that of A1,B29-diacetylinsulin and insulin. The cross-linked insulin is, in general, more resistant than insulin itself or the diacetylated derivative. However, in the case of enzymatic degradation, A1,B29-diacetylinsulin resembles more the cross-linked derivative than insulin. This provides evidence that the properties of A1,B29-adipoylinsulin could not in all circumstances be attributed to its 'proinsulin-like' structure. |
| تدمد: | 1437-4315 1431-6730 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221b73a9925772527a2b7b1891aafcd8 https://doi.org/10.1515/bchm.1978.359.1.225 |
| رقم الأكسشن: | edsair.doi.dedup.....221b73a9925772527a2b7b1891aafcd8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374315 14316730 |
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