Medication intake and hemorrhage risk in patients with familial cerebral cavernous malformations
| العنوان: | Medication intake and hemorrhage risk in patients with familial cerebral cavernous malformations |
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| المؤلفون: | Alejandro N. Santos, Laurèl Rauschenbach, Dino Saban, Bixia Chen, Annika Lenkeit, Hanah Hadice Gull, Christoph Rieß, Cornelius Deuschl, Börge Schmidt, Ramazan Jabbarli, Karsten H. Wrede, Yuan Zhu, Benedikt Frank, Ulrich Sure, Philipp Dammann |
| المصدر: | Journal of Neurosurgery. 137:1088-1094 |
| بيانات النشر: | Journal of Neurosurgery Publishing Group (JNSPG), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Medizin, General Medicine |
| الوصف: | OBJECTIVE The objective of this study was to analyze the impact of medication intake on hemorrhage risk in patients with familial cerebral cavernous malformation (FCCM). METHODS The authors’ institutional database was screened for patients with FCCM who had been admitted to their department between 2003 and 2020. Patients with a complete magnetic resonance imaging (MRI) data set, evidence of multiple CCMs, clinical baseline characteristics, and follow-up (FU) examination were included in the study. The authors assessed the influence of medication intake on first or recurrent intracerebral hemorrhage (ICH) using univariate and multivariate logistic regression adjusted for age and sex. The longitudinal cumulative 5-year risk of hemorrhage was calculated by applying Kaplan-Meier and Cox regression analyses adjusted for age and sex. RESULTS Two hundred five patients with FCCMs were included in the study. Multivariate Cox regression analysis revealed ICH as a predictor for recurrent hemorrhage during the 5-year FU. The authors also noted a tendency toward a decreased association with ICH during FU in patients on statin medication (HR 0.22, 95% CI 0.03–1.68, p = 0.143), although the relationship was not statistically significant. No bleeding events were observed in patients on antithrombotic therapy. Kaplan-Meier analysis and log-rank test showed a tendency toward a low risk of ICH during FU in patients on antithrombotic therapy (p = 0.085), as well as those on statin therapy (p = 0.193). The cumulative 5-year risk of bleeding was 22.82% (95% CI 17.33%–29.38%) for the entire cohort, 31.41% (95% CI 23.26%–40.83%) for patients with a history of ICH, 26.54% (95% CI 11.13%–49.7%) for individuals on beta-blocker medication, 6.25% (95% CI 0.33%–32.29%) for patients on statin medication, and 0% (95% CI 0%–30.13%) for patients on antithrombotic medication. CONCLUSIONS ICH at diagnosis was identified as a risk factor for recurrent hemorrhage. Although the relationships were not statistically significant, statin and antithrombotic medication tended to be associated with decreased bleeding events. |
| تدمد: | 1933-0693 0022-3085 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228902439b2535311c4c967df1f883b9 https://doi.org/10.3171/2022.1.jns212724 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....228902439b2535311c4c967df1f883b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19330693 00223085 |
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