Mechanical properties of single electrospun drug-encapsulated nanofibres
| العنوان: | Mechanical properties of single electrospun drug-encapsulated nanofibres |
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| المؤلفون: | Kam W. Leong, Todd C. Hufnagel, Sing Yian Chew, Chwee Teck Lim |
| المصدر: | Nanotechnology. 17:3880-3891 |
| بيانات النشر: | IOP Publishing, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Scaffold, Materials science, biology, Mechanical Engineering, technology, industry, and agriculture, Modulus, Bioengineering, Nanotechnology, General Chemistry, Article, Tissue engineering, Chemical engineering, Mechanics of Materials, Ultimate tensile strength, biology.protein, Copolymer, General Materials Science, Nanometre, Electrical and Electronic Engineering, Bovine serum albumin, Tensile testing |
| الوصف: | The mechanical and structural properties of a surface play an important role in determining the morphology of attached cells, and ultimately their cellular functions. As such, mechanical and structural integrity are important design parameters for a tissue scaffold. Electrospun fibrous meshes are widely used in tissue engineering. When in contact with electrospun scaffolds, cells see the individual micro- or nanofibres as their immediate microenvironment. In this study, tensile testing of single electrospun nanofibres composed of poly(ε-caprolactone) (PCL), and its copolymer, poly(caprolactone-co-ethyl ethylene phosphate) (PCLEEP), revealed a size effect in the Young's modulus, E, and tensile strength, σ(T). Both strength and stiffness increase as the fibre diameter decreases from bulk (∼5 μm) into the nanometre region (200-300 nm). In particular, E and σ(T) of individual PCL nanofibres were at least two-fold and an order of magnitude higher than that of PCL film, respectively. PCL films were observed to have more pronounced crystallographic texture than the nanofibres; however no difference in crystalline fraction, perfection, or texture was detected among the various fibres. When drugs were encapsulated into single PCLEEP fibres, mechanical properties were enhanced with 1-20 wt% of loaded retinoic acid, but weakened by 10-20 wt% of encapsulated bovine serum albumin. This understanding of the effect of size and drug and protein encapsulation on the mechanical properties of electrospun fibres may help in the optimization of tissue scaffold design that combines biochemical and biomechanical cues for tissue regeneration. |
| تدمد: | 1361-6528 0957-4484 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229655595c1805a79baaad588c62e7fb https://doi.org/10.1088/0957-4484/17/15/045 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....229655595c1805a79baaad588c62e7fb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13616528 09574484 |
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