Carvedilol Administration Can Prevent Doxorubicin-Induced Cardiotoxicity: A Double-Blind Randomized Trial
| العنوان: | Carvedilol Administration Can Prevent Doxorubicin-Induced Cardiotoxicity: A Double-Blind Randomized Trial |
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| المؤلفون: | Homaei Shandiz F, Golkoo Hosseini, Mostafavi Toroghi H, Ahmadreza Zarifian, Tashakori Beheshti A, Afsoon Fazlinezhad |
| المصدر: | Cardiology. 134:47-53 |
| بيانات النشر: | S. Karger AG, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, medicine.medical_treatment, Adrenergic beta-Antagonists, Carbazoles, Breast Neoplasms, 030204 cardiovascular system & hematology, Placebo, Chemoprevention, law.invention, Propanolamines, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Double-Blind Method, Randomized controlled trial, law, medicine, Humans, Pharmacology (medical), Doxorubicin, Carvedilol, Chemotherapy, Cardiotoxicity, Antibiotics, Antineoplastic, Ejection fraction, business.industry, Stroke Volume, Middle Aged, medicine.disease, Treatment Outcome, 030220 oncology & carcinogenesis, Anesthesia, Female, Drug Monitoring, Cardiology and Cardiovascular Medicine, business, medicine.drug |
| الوصف: | Objective: The aim of this study is to evaluate the preventive effects of carvedilol on doxorubicin-induced cardiotoxicity. Methods: In this trial, 70 female patients with breast cancer who were candidates to receive doxorubicin were enrolled, from which 30 were selected randomly to receive carvedilol 6.25 mg daily during chemotherapy, with the rest receiving placebo as the control group. Both groups were evaluated 1 week before and 1 week after chemotherapy by measuring the left ventricular ejection fraction and strain/strain rate. Results: Data analysis showed that the case group presented no significant reduction in strain and strain-rate parameters after intervention, while there was a significant reduction in these parameters in the control group (all p values Conclusion: This study shows that carvedilol can prevent doxorubicin-induced cardiotoxicity. Whether this prophylaxis should be considered as the preferred method needs further investigation. |
| تدمد: | 1421-9751 0008-6312 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a8d4fe5bc8c4f29c994393dec8b39d https://doi.org/10.1159/000442722 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....22a8d4fe5bc8c4f29c994393dec8b39d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219751 00086312 |
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