Polyurethane foam for skin graft fixation in clinical-relevant ovine burn wound model for wound repair and regeneration research
| العنوان: | Polyurethane foam for skin graft fixation in clinical-relevant ovine burn wound model for wound repair and regeneration research |
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| المؤلفون: | Suzan Alharbi, Donald S. Prough, Satoshi Fukuda, Perenlei Enkhbaatar, Yosuke Niimi |
| المصدر: | Regenerative Therapy Regenerative Therapy, Vol 14, Iss, Pp 341-343 (2020) |
| بيانات النشر: | Japanese Society for Regenerative Medicine, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Polyurethane foam, Autologous skin graft, Biomedical Engineering, Biomaterials, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Allogenous skin graft, Medicine, In patient, lcsh:QH573-671, Graft fixation, Polyurethane, lcsh:R5-920, Burn wound, Sheep, Non-adhesive hydrocellular foam dressing, integumentary system, lcsh:Cytology, business.industry, Regeneration (biology), Surgery, 030104 developmental biology, surgical procedures, operative, chemistry, Wound dressing, Burn wound healing, lcsh:Medicine (General), business, Wound healing, 030217 neurology & neurosurgery, Developmental Biology, Large animal, Forum Report |
| الوصف: | The availability of clinical-relevant large animal models for research in wound healing study is limited. Although a few reports described the wound dressing fixation method using polyurethane foam in patients, no animal studies were conducted to investigate efficacy of the polyurethane foam in grafted burn wounds. In the present study, we report a simple fixation method of grafted burned skin using polyurethane foam dressing (Allevyn Non-Adhesive, smith & nephew, UK) in a clinically relevant ovine grafted burn wound model. The dressing was removed at postoperative day 7 after skin graft. The grafted skin was completely engrafted without any complications. This method was safe and easy to perform and associated with good engraftment without any complications. We believe that the polyurethane foam fixation method may be successfully used in clinical practice as well as in preclinical studies for grafted burn wound repair and regeneration research. Highlights • Polyurethane foam was effective for fixation of grafted skin in ovine burn wounds model. • Histopathology of ovine grafted skin model was similar to that of human. • Ovine is considered as a clinical-relevant animal model for wound regeneration research. • The polyurethane foam method can potentially be translated to clinical practice. |
| اللغة: | English |
| تدمد: | 2352-3204 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e946ab2dae5f74cfea8960c5dbf117 http://europepmc.org/articles/PMC7256436 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....22e946ab2dae5f74cfea8960c5dbf117 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23523204 |
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