KLF15 Inhibits Cell Proliferation in Gastric Cancer Cells via Up-Regulating CDKN1A/p21 and CDKN1C/p57 Expression
| العنوان: | KLF15 Inhibits Cell Proliferation in Gastric Cancer Cells via Up-Regulating CDKN1A/p21 and CDKN1C/p57 Expression |
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| المؤلفون: | Yan-Fen Wang, Yongqian Shu, Chenhui Zhao, Pei Ma, Qin-Nan Chen, Jie Liu, Chongqi Sun, Wei-Tao Liu, Yutian Pan, Wei Li, Yingchen Qian |
| المصدر: | Digestive Diseases and Sciences. 62:1518-1526 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Cyclin-Dependent Kinase Inhibitor p21, Male, 0301 basic medicine, medicine.medical_specialty, Physiology, Kruppel-Like Transcription Factors, KLF15, Adenocarcinoma, Biology, Transfection, law.invention, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, law, Cell Line, Tumor, Internal medicine, medicine, Humans, Cyclin-Dependent Kinase Inhibitor p57, Cell Proliferation, Neoplasm Staging, Cell growth, Stomach, Gastroenterology, Nuclear Proteins, Cancer, Middle Aged, Hepatology, Prognosis, medicine.disease, G1 Phase Cell Cycle Checkpoints, Up-Regulation, Gene Expression Regulation, Neoplastic, Ki-67 Antigen, 030104 developmental biology, Lymphatic Metastasis, 030220 oncology & carcinogenesis, S Phase Cell Cycle Checkpoints, Cancer cell, Cancer research, Immunohistochemistry, Suppressor, Female, Function (biology) |
| الوصف: | Kruppel-like factors (KLFs) have been identified in multi-cancers and act as oncogenes or tumor suppressors. The function of KLF15, one member of KLFs, has not been well elucidated, especially in gastric cancer (GC). This study was designed to investigate the prognostic value and biological functions of KLF15 in GC. KLF15 protein expression in GC patients was evaluated by immunohistochemistry assays in 50 paired GC tissues and adjacent normal tissues, and correlations between KLF15 expression and clinicopathological characteristics and prognosis were analyzed. Then, we investigated the over-expression of KLF15 on cell proliferation and its mechanism in GC cells. KLF15 expression levels were significantly down-regulated in GC tissues compared to adjacent normal tissues. And KLF15 expression was negatively correlated with clinical stage, lymphatic metastasis, and distant metastasis. Furthermore, KLF15 expression could predict prognosis in patients with GC. Moreover, over-expression of KLF15 could inhibit cell proliferation partly via regulating CDKN1A/p21 and CDKN1C/p57. These findings demonstrate that KLF15 plays a significant role in GC progression and could be a therapeutic target for GC. |
| تدمد: | 1573-2568 0163-2116 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2305bdfdf1c5ae02944c7edc4b3091e8 https://doi.org/10.1007/s10620-017-4558-2 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....2305bdfdf1c5ae02944c7edc4b3091e8 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15732568 01632116 |
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