Invasive Candida auris infections in Kuwait hospitals: epidemiology, antifungal treatment and outcome
| العنوان: | Invasive Candida auris infections in Kuwait hospitals: epidemiology, antifungal treatment and outcome |
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| المؤلفون: | Khalifa Al Benwan, Suhail Ahmad, Aneesa A. Abdullah, Khaled Alobaid, Ziauddin Khan, Eiman Mokaddas, Maha Emara, Ritu Bafna, Leena Joseph, Prashant Purohit, Inaam Al-Obaid |
| المصدر: | Infection. 46:641-650 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Antifungal Agents, 030106 microbiology, Microbial Sensitivity Tests, 03 medical and health sciences, 0302 clinical medicine, Amphotericin B, Internal medicine, Epidemiology, medicine, Humans, Infection control, Candidiasis, Invasive, 030212 general & internal medicine, Etest, Aged, Candida, Aged, 80 and over, Voriconazole, Cross Infection, Infection Control, business.industry, Outbreak, General Medicine, Middle Aged, Hospitals, Treatment Outcome, Infectious Diseases, Kuwait, Candida auris, Female, business, Fluconazole, medicine.drug |
| الوصف: | Candida auris is a recently recognized yeast pathogen, which has attracted worldwide attention due to its multidrug-resistant nature and associated high mortality rates. Its persistence in hospital environment and propensity of nosocomial transmission underscores the need of continuous monitoring to prevent outbreaks. Since the first case of C. auris candidemia in May, 2014, we have identified 17 additional invasive cases, which are described here. Identity of 17 isolates originating from proven or possible cases of invasive C. auris infection and identified as Candida haemulonii by Vitek 2 yeast identification system was confirmed by PCR-sequencing of rDNA. Information about risk factors, treatment and outcomes were retrospectively retrieved from case files. Antifungal susceptibility testing was performed by Etest. Thirteen cases of candidemia and 4 cases of other invasive infections were detected in 6 hospitals across Kuwait. Major risk factors included adult patients with cancer, diabetes, gastrointestinal/liver diseases and extended (> 25 days) hospital stay. All isolates were resistant to fluconazole. Additionally, 5 and 4 isolates were also resistant to voriconazole and amphotericin B, respectively. Despite antifungal treatment, 9 of 15 patients died. Most patients (n = 12) were hospitalized in 2 hospitals that are in close proximity, whereas 5 other patients were from 3 hospitals that are situated > 10 km apart. Occurrence of successive cases of invasive C. auris infections with resulting mortality in nine patients suggests persistence of this multidrug-resistant yeast in major hospitals in Kuwait. Early detection by continuous surveillance and enforcement of infection control measures are recommended. |
| تدمد: | 1439-0973 0300-8126 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233538bedbedaa4f5e9ee4af726fc97c https://doi.org/10.1007/s15010-018-1164-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....233538bedbedaa4f5e9ee4af726fc97c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390973 03008126 |
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