Genome‐wide identification of a novel mi RNA ‐based signature to predict recurrence in patients with gastric cancer
| العنوان: | Genome‐wide identification of a novel mi |
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| المؤلفون: | Guixi Zheng, Xiaoyun Yang, Xin Zhang, Yongmei Yang, Rui Zhao, Yi Zhang, Zhaogang Dong, Hongwei Pan, Ailin Qu, Hongchun Wang, Mengmeng Hua |
| المصدر: | Molecular Oncology Molecular Oncology, Vol 12, Iss 12, Pp 2072-2084 (2018) |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, recurrence‐free survival, lcsh:RC254-282, Genome, Disease-Free Survival, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, Internal medicine, microRNA, Biomarkers, Tumor, Genetics, medicine, Humans, Lymph node, Research Articles, Receiver operating characteristic, business.industry, Proportional hazards model, Gene Expression Profiling, gastric cancer, Area under the curve, prediction, General Medicine, Nomogram, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Prognosis, medicine.disease, Gene Expression Regulation, Neoplastic, MicroRNAs, miRNA signature, 030104 developmental biology, medicine.anatomical_structure, ROC Curve, 030220 oncology & carcinogenesis, Molecular Medicine, Female, Neoplasm Recurrence, Local, business, Research Article |
| الوصف: | The current tumor node metastasis (TNM) staging system is inadequate for identifying high‐risk gastric cancer (GC) patients. Using a systematic and comprehensive‐biomarker discovery and validation approach, we attempted to build a microRNA (miRNA)‐recurrence classifier (MRC) to improve the prognostic prediction of GC. We identified 312 differentially expressed miRNAs in 446 GC tissues compared to 45 normal controls by analyzing high‐throughput data from The Cancer Genome Atlas (TCGA). Using a Cox regression model, we developed an 11‐miRNA signature that could successfully discriminate high‐risk patients in the training set (n = 372; P |
| تدمد: | 1878-0261 1574-7891 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236c6188c6555c816c1f01f2140b2448 https://doi.org/10.1002/1878-0261.12385 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....236c6188c6555c816c1f01f2140b2448 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18780261 15747891 |
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