Clarithromycin attenuates myocardial ischemia–reperfusion injury
| العنوان: | Clarithromycin attenuates myocardial ischemia–reperfusion injury |
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| المؤلفون: | Ayako Nagashima, Takuya Nakajima, Mitsuaki Isobe, Ryozo Nagai, Masahito Ogawa, Yasunobu Hirata, Keiichi Hishikari, Mayumi Masumura, Ryo Watanabe, Kiyoshi Takayama, Jun-ichi Suzuki |
| المصدر: | Expert Opinion on Therapeutic Targets. 14:881-893 |
| بيانات النشر: | Informa UK Limited, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Clinical Biochemistry, Myocardial Infarction, Ischemia, Infarction, Myocardial Reperfusion Injury, Inflammation, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Rats, Sprague-Dawley, Ventricular Dysfunction, Left, Downregulation and upregulation, Clarithromycin, Internal medicine, Drug Discovery, medicine, Animals, Protein Synthesis Inhibitors, Pharmacology, Metalloproteinase, business.industry, Macrophages, medicine.disease, Fibrosis, Rats, Anesthesia, Cardiology, Molecular Medicine, medicine.symptom, business, Reperfusion injury, medicine.drug |
| الوصف: | MMP activity is upregulated in the heart after myocardial ischemia reperfusion, and its activation contributes to the changes in left ventricular (LV) dysfunction. A major macrolide antibiotic, clarithromycin has many biological functions including MMP regulation. However, little is known about the effect of clarithromycin in myocardial reperfusion injury via MMPs. Our objective was to clarify the role of MMPs regulated by clarithromycin in the progression of myocardial reperfusion injury.We administered clarithromycin to rats with ischemia-reperfusion injury twice a day for 7 days before and 14 days after reperfusion.Clarithromycin resulted in a significant reduction of the infarction area:area at risk ratio and preserved fractional shortening ratio after 14 days of reperfusion. Immunohistochemical analysis revealed that macrophages were the primary cellular source of MMPs. Fewer macrophages were detected in the ischemic area of the hearts following ischemia reperfusion in the clarithromycin-treated group compared with the vehicle-treated group. Although ischemia-reperfusion injury resulted in LV fibrosis with increasing MMP activities, clarithromycin significantly reduced these changes.Clarithromycin is effective for attenuating myocardial ischemia-reperfusion injury by suppressing MMPs. |
| تدمد: | 1744-7631 1472-8222 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c25f31446a3141e6f72e5cae07b32d https://doi.org/10.1517/14728222.2010.502890 |
| رقم الأكسشن: | edsair.doi.dedup.....23c25f31446a3141e6f72e5cae07b32d |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17447631 14728222 |
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