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Cytochrome P450 4F2 polymorphism in patients with liver cirrhosis

التفاصيل البيبلوغرافية
العنوان: Cytochrome P450 4F2 polymorphism in patients with liver cirrhosis
المؤلفون: Yu. Yu. Karavaeva, E. V. Vinogradova, V. V. Lyakhovich, Zh. V. Nokhrina, D. L. Nepomnyashchikh, S. I. Makarova, V. A. Vavilin, E. G. Shchepotina, A. V. Kudryashov
المصدر: Bulletin of experimental biology and medicine. 156(2)
سنة النشر: 2013
مصطلحات موضوعية: Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis, Adolescent, Genotype, Polyunsaturated Alkamides, CYP4F2, Arachidonic Acids, Gastroenterology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Young Adult, Cytochrome P-450 Enzyme System, Gene Frequency, Internal medicine, medicine, Humans, In patient, Genetic Predisposition to Disease, Cytochrome P450 Family 4, Allele, Aged, Cannabinoid Receptor Agonists, biology, business.industry, CYP4F2 gene, Cytochrome P450, General Medicine, Middle Aged, medicine.disease, biology.protein, Etiology, Female, business, Endocannabinoids
الوصف: 1297C/T polymorphism of CYP4F2 gene was studied in 108 patients with chronic liver diseases. No significant correlation with predisposition to rapid liver cirrhosis was revealed without consideration for cirrhosis etiology (OR = 0.93, 95% CI = 0.28-2.99, p = 0.885). In patients with viral cirrhosis, a tendency to association of 1297T allele genotypes with rapid cirrhosis development was found (OR = 6.0, 95% CI = 0.28-382.64, p = 0.222). At the same time, CYP4F2 1297T allele was associated with mild (Child–Pugh class A-B) cirrhosis (OR = 2.9, p = 0.044).
تدمد: 1573-8221
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f3b580b3a042b7f50a792e0e17c16e
https://pubmed.ncbi.nlm.nih.gov/24319743
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....23f3b580b3a042b7f50a792e0e17c16e
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15738221