Interaction of historical and modern Sardinian African swine fever viruses with porcine and wild-boar monocytes and monocyte-derived macrophages
| العنوان: | Interaction of historical and modern Sardinian African swine fever viruses with porcine and wild-boar monocytes and monocyte-derived macrophages |
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| المؤلفون: | Paola Nicolussi, Mauro Ledda, D. Bacciu, Giovannantonio Pilo, Giovanna Sanna, Giulia Franzoni, Piero Bonelli, Silvia Dei Giudici, Pier Paolo Angioi, Annalisa Oggiano |
| المصدر: | Archives of Virology |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Swine, medicine.medical_treatment, Sus scrofa, Biology, Monocytes, Virus, Late protein, Viral Proteins, 03 medical and health sciences, Medical microbiology, Wild boar, Virology, biology.animal, medicine, Animals, African Swine Fever, Gene, Cells, Cultured, 030304 developmental biology, 0303 health sciences, 030306 microbiology, Macrophages, Strain (biology), General Medicine, African Swine Fever Virus, Cytokine, Italy, Cytokines, Original Article, Viral disease |
| الوصف: | African swine fever (ASF) is a contagious viral disease of wild and domestic pigs that is present in many parts of Africa, Asia and Europe, including Sardinia (Italy). Deletions in the EP402R and B602L genes have been found in almost all ASF virus (ASFV) strains circulating in Sardinia from 1990 onwards, and modern Sardinian strains (isolated after 1990) might have acquired some selective advantage compared to historical ones (isolated before 1990). Here, we analysed the host cell responses of wild boars and domestic pigs upon infection with virus variants. Higher intracellular levels of the late protein p72 were detected after infection with the modern strain 22653/14 compared to the historical strain Nu81.2, although both isolates grew at the same rate in both monocytes and monocyte-derived macrophages. Higher cytokine levels in the supernatants of ASFV-infected pig monocytes compared to pig macrophages and wild-boar cells were detected, with no differences between isolates. |
| تدمد: | 1432-8798 0304-8608 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fb189c73ee2598f2cc2ace52464fa9 https://doi.org/10.1007/s00705-018-04140-6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....23fb189c73ee2598f2cc2ace52464fa9 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14328798 03048608 |
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