Mortality and its Causes in a German Cohort with Diabetes Mellitus Type 1 after 20 Years of Follow-Up: The JEVIN Trial
| العنوان: | Mortality and its Causes in a German Cohort with Diabetes Mellitus Type 1 after 20 Years of Follow-Up: The JEVIN Trial |
|---|---|
| المؤلفون: | Nicolle Müller, Ralf Schiel, Thomas Lehmann, Stefan Lorkowski, Ulrich A. Müller, T Heller, Gunter Wolf, Christof Kloos |
| المصدر: | Experimental and Clinical Endocrinology & Diabetes. 126:387-393 |
| بيانات النشر: | Georg Thieme Verlag KG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Diabetes Complications, Diabetic nephropathy, 03 medical and health sciences, Life Expectancy, 0302 clinical medicine, Endocrinology, Cause of Death, Germany, Diabetes mellitus, Internal medicine, Internal Medicine, Humans, Medicine, education, Aged, Cause of death, Aged, 80 and over, Type 1 diabetes, education.field_of_study, business.industry, Incidence, Incidence (epidemiology), General Medicine, Middle Aged, medicine.disease, Surgery, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Cardiovascular Diseases, Cohort, Disease Progression, Female, business, Follow-Up Studies |
| الوصف: | Background The JEVIN trial started as a cross-sectional study in 1989/90 in Jena. After a follow-up of more than 20 years, the mortality incidence of JEVIN participants with type 1 diabetes was surveyed. Methods 103 (78.6%) of the 131 JEVIN patients participating at baseline could be examined. 38 persons (36.9%) had deceased. All JEVIN survey data and routine examinations documented in the electronic patient record EMIL® of surviving and deceased participants were used for analyses. We compared the data of the surviving with the deceased participants (follow-up time: 2,166 person-years). Results The incidence rate of death was 1.75/100 person-years. Median observation time for all patients was 23.1 years (range 0.61–26.6 years). Mean age at death was 58.5 years (34.2–78.4 years), and diabetes duration 35 years (3.5–68.5 years). Most frequent causes of death were: cardiovascular diseases (48.2%, n=13) and infections (25.9%, n=7). There were no differences in age (p=0.302), diabetes duration (p=0.371), BMI (p=0.535), blood pressure (p=0.622/0.820), gender (p=0.566), and smoking status (p=0.709) between surviving and deceased persons. The mean HbA1c of the last year before death or last visit was higher in the deceased than surviving persons (7.5% vs. 7.0%; p=0.010). 57.4% of the surviving and 87.0% of the deceased participants had nephropathy (p=0.012), 79.7% vs. 89.7% retinopathy (p=0.241) and 61.4% vs. 63.3% neuropathy (p=0.860), but only nephropathy was significantly associated with increased mortality risk (HR=4.208, CI:1.226-14.440; HR=2.360, CI:0.696-8.004; HR=0.944, CI:0.436-2.043). Conclusions In the JEVIN population with diabetes mellitus type 1 only, diabetic nephropathy was associated with higher mortality risk. |
| تدمد: | 1439-3646 0947-7349 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fe91ebf023bfdd7b05eca1008e2d95 https://doi.org/10.1055/s-0043-113452 |
| رقم الأكسشن: | edsair.doi.dedup.....23fe91ebf023bfdd7b05eca1008e2d95 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14393646 09477349 |
|---|