Tensile strength of tablets containing two materials with a different compaction behaviour

التفاصيل البيبلوغرافية
العنوان: Tensile strength of tablets containing two materials with a different compaction behaviour
المؤلفون: Henderik W. Frijlink, B. van Veen, Gerad Klaas Bolhuis, K. Zuurman, K. van der Voort Maarschalk
المساهمون: Pharmaceutical Technology and Biopharmacy, Biopharmaceuticals, Discovery, Design and Delivery (BDDD)
المصدر: International Journal of Pharmaceutics, 203(1-2), 71-79. Elsevier Bedrijfsinformatie b.v.
سنة النشر: 2000
مصطلحات موضوعية: Relaxation, Yield (engineering), Materials science, Starch, Compaction, Pharmaceutical Science, Mineralogy, Sodium Chloride, tablet machine, chemistry.chemical_compound, Tablet strength, Ultimate tensile strength, Densification, Pressure, controlled study, gelatinization, tablet formulation, Composite material, Porosity, nonhuman, starch, article, Binary mixture, tablet porosity, particle size, Compression (physics), chemistry, priority journal, tensile strength, leisure, Relaxation (physics), Particle size, Interparticle bonding, tablet compression, scanning electron microscopy, Tablets
الوصف: The tensile strength of tablets compressed from binary mixtures is in general not linearly related to the strength of tablets prepared from single materials; in many cases it shows a decreased tensile strength relative to interpolation. The materials used in this study, sodium chloride and pregelatinised starch, are both plastically deforming materials, but have a different densification and relaxation behaviour. The yield pressure of the binary mixtures shows an almost linear relationship. As an effect of their lower yield pressure, starch particles yield earlier than sodium chloride particles. The following enclosure prevents some sodium chloride particles to yield or crack. The relaxation of the tablets is higher than the relaxation calculated by linear interpolation of the relaxation behaviour of the two pure materials. The difference between the measured porosity expansion and the data obtained by linear interpolation can be considered as a measure for the reduced interparticle bonding. SEM-photographs indicate that the reduced interparticle bonding is caused by the low adhesive forces. The measured decrease of the tensile strength of the tablets is also considered to be the result of reduced interparticle bonding. In this paper it is shown that there exists a similar relationship between the tensile strength reduction and the percentage of starch on the one hand and the extra porosity expansion and the starch percentage on the other hand. (C) 2000 Elsevier Science B.V. All rights reserved.
اللغة: English
تدمد: 0378-5173
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240f2f4ac9f59b6519eb1c4b040b0cf6
https://research.rug.nl/en/publications/ff679ecf-d13e-4872-8ab8-149b5b5977f3
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....240f2f4ac9f59b6519eb1c4b040b0cf6
قاعدة البيانات: OpenAIRE