Cutaneous side-effects in patients with rheumatic diseases during application of tumour necrosis factor-? antagonists
| العنوان: | Cutaneous side-effects in patients with rheumatic diseases during application of tumour necrosis factor-? antagonists |
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| المؤلفون: | Hae-Hyuk Lee, Röwert J, Gerd-Ruediger Burmester, Kary S, Heike Audring, Wolfram Sterry, Margitta Worm, Detert J, Song Ih, Gauliard A, Markus Friedrich |
| المصدر: | British Journal of Dermatology. 156:486-491 |
| بيانات النشر: | Oxford University Press (OUP), 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Dermatology, Opportunistic Infections, Antibodies, Monoclonal, Humanized, Receptors, Tumor Necrosis Factor, Dermatitis, Atopic, Etanercept, Psoriatic arthritis, Rheumatic Diseases, Psoriasis, Dermatitis herpetiformis, medicine, Adalimumab, Humans, Immunologic Factors, Prospective Studies, Skin Diseases, Infectious, Aged, Ankylosing spondylitis, Tumor Necrosis Factor-alpha, business.industry, Antibodies, Monoclonal, Middle Aged, medicine.disease, Infliximab, Antirheumatic Agents, Immunoglobulin G, Rheumatoid arthritis, Immunology, Female, Drug Eruptions, business, medicine.drug |
| الوصف: | Background Patients with rheumatic diseases receiving antitumour necrosis factor (TNF)-a-based treatment may develop cutaneous reactions. Objectives To analyse the new onset or aggravation of skin lesions in patients with a rheumatic disease during treatment with TNF-a antagonists. Methods We conducted a prospective analysis of 35 of 150 patients with a long history of rheumatic disease, including rheumatoid arthritis, ankylosing spondylitis (Bechterew’s disease) and psoriatic arthritis, to test for the development of cutaneous manifestations during anti-TNF-a (infliximab, adalimumab or etanercept) treatment. Results Chronic inflammatory skin diseases such as psoriasis and eczema-like manifestations represented the majority of cases (16 of 35). Cutaneous infections caused by viral, bacterial and fungal agents were also observed in many patients (13 of 35). Skin diseases such as dermatitis herpetiformis, leucocytoclastic vasculitis and alopecia occurred in single cases only. Conclusions We observed a broad, diverse clinical spectrum with a majority of chronic inflammatory and infectious skin diseases. However, we did not identify individual risk factors and a discontinuation of the anti-TNF-a treatment was not necessary if adequate dermatological treatment was performed. The onset of cutaneous side-effects in anti-TNF-a-based treatments should be determined by nationwide registries. |
| تدمد: | 1365-2133 0007-0963 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2450ea7a9da3bd20325deab0271758f1 https://doi.org/10.1111/j.1365-2133.2007.07682.x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2450ea7a9da3bd20325deab0271758f1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652133 00070963 |
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