Sirt1 during childhood is associated with microvascular function later in life
| العنوان: | Sirt1 during childhood is associated with microvascular function later in life |
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| المؤلفون: | Jacob Looney, Jeffrey Thomas, Paula Rodriguez-Miguelez, Gregory A. Harshfield, Jennifer S. Pollock, Ryan A. Harris |
| المصدر: | Am J Physiol Heart Circ Physiol |
| بيانات النشر: | American Physiological Society, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Pediatrics, medicine.medical_specialty, Adolescent, Physiology, business.industry, Microcirculation, Hyperemia, Acetylcholine, Vasodilation, Young Adult, Sirtuin 1, Physiology (medical), Microvessels, Laser-Doppler Flowmetry, Humans, Medicine, Female, Endothelium, Vascular, Longitudinal cohort, Cardiology and Cardiovascular Medicine, business, Research Article |
| الوصف: | Microvascular dysfunction often precedes other age-related macrovascular conditions and predicts future cardiovascular risk. Sirtuin 1 (Sirt1) has recently emerged as a protein that protects the vasculature and reduces the risk of cardiovascular diseases. We tested the hypothesis that lower Sirt1 during childhood is associated with a reduced microvascular function during adulthood. Thirty-four adults (34 ± 3 yr) from the Augusta Heart Study returned to participate in the present clinical observational study. Sirt1 was assessed in samples collected during both adulthood and participants’ childhood (16 ± 3 yr), and data were divided based on childhood Sirt1 concentrations |
| تدمد: | 1522-1539 0363-6135 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247b79b3c9a9530d078683a02d48a717 https://doi.org/10.1152/ajpheart.00024.2020 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....247b79b3c9a9530d078683a02d48a717 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221539 03636135 |
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