Scavenging nucleic acid debris to combat autoimmunity and infectious disease
| العنوان: | Scavenging nucleic acid debris to combat autoimmunity and infectious disease |
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| المؤلفون: | Angela D. Burnette, Eda K. Holl, Christopher J. Sample, Elizabeth Ramsburg, Bruce A. Sullenger, Luke B. Borst, Kara L. Shumansky |
| المصدر: | Proceedings of the National Academy of Sciences. 113:9728-9733 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Dendrimers, Autoimmunity, Mice, Transgenic, Inflammation, Biology, medicine.disease_cause, Corrections, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Nucleic Acids, Lupus Erythematosus, Cutaneous, medicine, Animals, Humans, Immunologic Factors, DNA Cleavage, Skin, RNA Cleavage, Autoimmune disease, Multidisciplinary, Innate immune system, Effector, Pattern recognition receptor, food and beverages, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Antibodies, Antinuclear, 030220 oncology & carcinogenesis, Physical Sciences, Immunology, Nucleic acid, medicine.symptom, Protein Binding |
| الوصف: | Nucleic acid-containing debris released from dead and dying cells can be recognized as damage-associated molecular patterns (DAMPs) or pattern-associated molecular patterns (PAMPs) by the innate immune system. Inappropriate activation of the innate immune response can engender pathological inflammation and autoimmune disease. To combat such diseases, major efforts have been made to therapeutically target the pattern recognition receptors (PRRs) such as the Toll-like receptors (TLRs) that recognize such DAMPs and PAMPs, or the downstream effector molecules they engender, to limit inflammation. Unfortunately, such strategies can limit the ability of the immune system to combat infection. Previously, we demonstrated that nucleic acid-binding polymers can act as molecular scavengers and limit the ability of artificial nucleic acid ligands to activate PRRs. Herein, we demonstrate that nucleic acid scavengers (NASs) can limit pathological inflammation and nucleic acid-associated autoimmunity in lupus-prone mice. Moreover, we observe that such NASs do not limit an animal's ability to combat viral infection, but rather their administration improves survival when animals are challenged with lethal doses of influenza. These results indicate that molecules that scavenge extracellular nucleic acid debris represent potentially safer agents to control pathological inflammation associated with a wide range of autoimmune and infectious diseases. |
| تدمد: | 1091-6490 0027-8424 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c2db5eff7bcbb24c591d6f15e7451e https://doi.org/10.1073/pnas.1607011113 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....24c2db5eff7bcbb24c591d6f15e7451e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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