Unusual Polyhydroxylated Steroids from the Starfish Anthenoides laevigatus, Collected off the Coastal Waters of Vietnam
| العنوان: | Unusual Polyhydroxylated Steroids from the Starfish Anthenoides laevigatus, Collected off the Coastal Waters of Vietnam |
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| المؤلفون: | Pham Quoc Long, Olesya S. Malyarenko, Tran Thi Thu Thuy, Dinh T. Ha, Timofey V. Malyarenko, Nguyen Thi Thu Ha, Roman S. Popov, Anatoly I. Kalinovsky, Natalia V. Ivanchina, Alla A. Kicha |
| المصدر: | Molecules Molecules, Vol 25, Iss 6, p 1440 (2020) Volume 25 Issue 6 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_treatment, Starfish, polyhydroxylated steroids, Anthenoides laevigatus, Pharmaceutical Science, Antineoplastic Agents, Soft Agar Assay, 01 natural sciences, Article, Analytical Chemistry, Steroid, lcsh:QD241-441, lcsh:Organic chemistry, Neoplasms, Drug Discovery, medicine, Animals, Humans, Cytotoxic T cell, Physical and Theoretical Chemistry, Cytotoxicity, Nuclear Magnetic Resonance, Biomolecular, Cell Proliferation, Molecular Structure, biology, NMR spectra, 010405 organic chemistry, Cell growth, Chemistry, Organic Chemistry, Cancer, Nuclear magnetic resonance spectroscopy, medicine.disease, biology.organism_classification, soft agar assay, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Vietnam, Biochemistry, Chemistry (miscellaneous), cytotoxicity, Molecular Medicine, Steroids, anthenoides laevigatus, HT29 Cells |
| الوصف: | Four new polyhydroxylated steroids 1&ndash 4 were isolated along with two previously known related steroids 5 and 6 from the methanolic extract of the starfish Anthenoides laevigatus collected off the coastal waters of Vietnam. Structures of new compounds were substantially elucidated by one-dimensional (1D) and two-dimensional (2D) NMR spectroscopy and HRESIMS techniques. Heptaol 1 and hexaol 2 contain the common 5&alpha cholestane skeleton, while hexaol 3 and heptaol 4 have the rare among starfish steroid compounds 5&beta cholestane skeleton. Compounds 1, 5, and 6 do not show cytotoxic effects against normal JB6 Cl41 and cancer HT-29 and MDA-MB-231 cells, however they inhibit cell proliferation and colony formation of cancer HT-29 and MDA-MB-231 cells. |
| وصف الملف: | application/pdf |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ef50471cee4379dea32201a383a41b https://doi.org/10.3390/molecules25061440 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....24ef50471cee4379dea32201a383a41b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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