Prediction of Transporter-Mediated Drug-Drug Interactions and Phenotyping of Hepatobiliary Transporters Involved in the Clearance of E7766, a Novel Macrocycle-Bridged Dinucleotide
| العنوان: | Prediction of Transporter-Mediated Drug-Drug Interactions and Phenotyping of Hepatobiliary Transporters Involved in the Clearance of E7766, a Novel Macrocycle-Bridged Dinucleotide |
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| المؤلفون: | Laurette Burgess, Dae-Shik Kim, Vaishali Dixit, Andrew Hart, Rongrong Jiang, Weidong George Lai |
| المصدر: | Drug Metabolism and Disposition. 49:265-275 |
| بيانات النشر: | American Society for Pharmacology & Experimental Therapeutics (ASPET), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Drug, Macrocyclic Compounds, Swine, media_common.quotation_subject, Pharmaceutical Science, Mice, Transgenic, Drug Elimination Routes, Pharmacology, 030226 pharmacology & pharmacy, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, Pharmacokinetics, In vivo, Animals, Humans, Drug Interactions, Biliary Tract, media_common, Dose-Response Relationship, Drug, Chemistry, Vesicle, Transporter, Transfection, Drug interaction, In vitro, Rats, Hepatobiliary Elimination, HEK293 Cells, Phenotype, Liver, 030220 oncology & carcinogenesis, Hepatocytes, LLC-PK1 Cells, Rifampin, Forecasting |
| الوصف: | E7766 represents a novel class of macrocycle-bridged dinucleotides and is under clinical development for immuno-oncology. In this report, we identified mechanism of systemic clearance E7766 and investigated the hepatobiliary transporters involved in the disposition of E7766 and potential drug interactions of E7766 as a victim of organic anion-transporting polypeptide (OATP) inhibitors. In bile-duct cannulated rats and dogs, E7766 was mainly excreted unchanged in bile (>80%) and to a lesser extent in urine ( |
| تدمد: | 1521-009X 0090-9556 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2520c9700e2159ee64f5114da91c6875 https://doi.org/10.1124/dmd.120.000125 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2520c9700e2159ee64f5114da91c6875 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1521009X 00909556 |
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