COMSOL Multiphysics® Modelling of Oxygen Diffusion Through a Cellulose Nanofibril Conduit Employed for Peripheral Nerve Repair
| العنوان: | COMSOL Multiphysics® Modelling of Oxygen Diffusion Through a Cellulose Nanofibril Conduit Employed for Peripheral Nerve Repair |
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| المؤلفون: | Nicklaus Carter, David J. Neivandt, Julia Towne |
| المصدر: | BioMedical Engineering OnLine, Vol 20, Iss 1, Pp 1-18 (2021) BioMedical Engineering |
| بيانات النشر: | Research Square Platform LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Materials science, Multiphysics, Flow (psychology), Biomedical Engineering, Biomaterials, 03 medical and health sciences, Oxygen permeability, Cellulose nanofibril (CNF), 0302 clinical medicine, Electrical conduit, Peripheral Nerve Injuries, Medical technology, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Diffusion (business), R855-855.5, Cellulose, health care economics and organizations, 030304 developmental biology, 0303 health sciences, Oxygen diffusion, Neural conduit, Radiological and Ultrasound Technology, Peripheral nerve injury and repair, Research, COMSOL Multiphysics® modelling, General Medicine, Oxygen, surgical procedures, operative, Permeability (electromagnetism), cardiovascular system, Current (fluid), Axial symmetry, 030217 neurology & neurosurgery, Biomedical engineering |
| الوصف: | Background Peripheral nerve injury can cause significant impairment, and the current methods for facilitating repair, particularly over distances greater than approximately 1 mm, are not entirely effective. Allografts, autografts, and synthetic conduits are three of the most common surgical interventions for peripheral nerve repair; however, each has limitations including poor biocompatibility, adverse immune responses, and the need for successive surgeries. A potential new method for promoting peripheral nerve repair that addresses the shortcomings of current interventions is a biocompatible cellulose nanofibril (CNF) conduit that degrades in-vivo over time. Preliminary testing in multiple animal models has yielded positive results, but more information is needed regarding how the CNF conduit facilitates nutrient and gas flow. Results The current work employs 3D modelling and analysis via COMSOL Multiphysics® to determine how the CNF conduit facilitates oxygen movement both radially through the conduit walls and axially along the length of the conduit. Various CNF wall permeabilities, conduit lengths, and nerve-to-conduit diameter ratios have been examined; all of which were shown to have an impact on the resultant oxygen profile within the conduit. When the walls of the CNF conduit were modeled to have significant oxygen permeability, oxygen diffusion across the conduit was shown to dominate relative to axial diffusion of oxygen along the length of the conduit, which was otherwise the controlling diffusion mechanism. Conclusions The results of this study suggest that there is a complex relationship between axial and radial diffusion as the properties of the conduit such as length, diameter, and permeability are altered and when investigating various locations within the model. At low wall permeabilities the axial diffusion is dominant for all configurations, while for higher wall permeabilities the radial diffusion became dominant for smaller diameters. The length of the conduit did not alter the mechanism of diffusion, but rather had an inverse relationship with the magnitude of the overall concentration profile. As such the modeling results may be employed to predict and control the amount and distribution of oxygenation throughout the conduit, and hence to guide experimental conduit design. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25216feef4427d592636e6a9acb435d7 https://doi.org/10.21203/rs.3.rs-345630/v1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....25216feef4427d592636e6a9acb435d7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |