Expression of CD19+CD5+B Cells and IgA1-positive cells in Tonsillar Tissues of IgA Nephropathy Patients
| العنوان: | Expression of CD19+CD5+B Cells and IgA1-positive cells in Tonsillar Tissues of IgA Nephropathy Patients |
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| المؤلفون: | Gang Wu, Youming Peng, Fu You Liu, Hui Xin Bi, Qi Di Hou, Hong Liu, Nan Lan Chen |
| المصدر: | Renal Failure. 33:159-163 |
| بيانات النشر: | Informa UK Limited, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Adolescent, Antigens, CD19, Palatine Tonsil, chemical and pharmacologic phenomena, CD5 Antigens, Kidney, Critical Care and Intensive Care Medicine, CD19, Pathogenesis, Young Adult, stomatognathic system, Antigen, immune system diseases, hemic and lymphatic diseases, medicine, Humans, Child, B-Lymphocytes, biology, Germinal center, Glomerulonephritis, IGA, hemic and immune systems, General Medicine, Middle Aged, Immunoglobulin A, Lymphatic system, medicine.anatomical_structure, Nephrology, Mesangium, Case-Control Studies, Tonsil, biology.protein, Female, CD5 |
| الوصف: | The hallmark of IgA nephropathy (IgAN) is the mesangial deposits of polymeric IgA. However, the source of IgA1 and the mechanism of deposition of IgA1 in the mesangium remain unknown. To better understand its pathogenesis, we investigated the expression of CD19(+)CD5(+)B cells and IgA1-positive cells in the tonsils of IgAN patients. Immunofluorescence was used to visualize the locations of CD19(+)CD5(+)B cells and IgA1-positive cells in the tonsils. In this study, it was demonstrated that CD19(+)CD5(+)B cells are usually found in germinal centers and in the capsule covering the upper parts of the nodules of lymphoid tissue (cap of the nodule). The expression of IgA1-positive cells in tonsil tissue can be seen in the cap of the nodule and subepithelial tissue. There is a significant relationship between IgA1 and CD19(+)CD5(+)B cells. The level of CD19(+)CD5(+)B cells is positively correlated to the severity of renal pathological changes. These findings suggest that CD19(+)CD5(+)B cells in the tonsils could have an impact on the pathogenesis of IgAN. |
| تدمد: | 1525-6049 0886-022X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2540241d705846ad1be6ee4c4f7dd1b2 https://doi.org/10.3109/0886022x.2011.552150 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2540241d705846ad1be6ee4c4f7dd1b2 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15256049 0886022X |
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