Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland
| العنوان: | Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland |
|---|---|
| المؤلفون: | D. Jackson, T. Crafton, Richard Poulsom, Clive Dickson, I. Rosewell, J. Bresnick, G. Stamp |
| المصدر: | Journal of Cell Science. 110:1261-1268 |
| بيانات النشر: | The Company of Biologists, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Genetically modified mouse, medicine.medical_specialty, animal structures, Mammary gland, Gene Expression, Mice, Transgenic, Biology, Fibroblast growth factor, Mice, Mammary Glands, Animal, Pregnancy, Internal medicine, medicine, Animals, RNA, Messenger, Receptor, Fibroblast Growth Factor, Type 1, Transgenes, Receptor, Fibroblast Growth Factor, Type 2, Promoter Regions, Genetic, Kinase, Mouse mammary tumor virus, Caseins, Proteins, Receptor Protein-Tyrosine Kinases, Cell Biology, Milk Proteins, biology.organism_classification, Receptors, Fibroblast Growth Factor, Phenotype, Cell biology, Fibroblast Growth Factors, medicine.anatomical_structure, Endocrinology, Mammary Tumor Virus, Mouse, Mammary Epithelium, Fibroblast growth factor receptor, RNA, Female, Signal Transduction |
| الوصف: | We have used the mouse mammary tumor virus promoter to express two dominant negative (DN) fibroblast growth factor receptor (FGFR) isoforms in the mammary epithelium of transgenic mice. While expression of DN-FGFR1(IIIc) showed no discernible phenotype, a similar kinase negative form of FGFR2(IIIb) caused a marked impairment of lobuloalveolar development. The growth retardation was apparent by mid-pregnancy and persisted in the post-partum glands. Despite the substantial underdevelopment of the mammary gland there was a measurable lactational response, but it was insufficient to properly sustain the new-born pups. These findings demonstrate that fibroblast growth factor signalling is necessary for pregnancy dependent lobuloalveolar development of the mammary gland. |
| تدمد: | 1477-9137 0021-9533 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254f54c65c4b5e88b0176d321ea2b565 https://doi.org/10.1242/jcs.110.11.1261 |
| رقم الأكسشن: | edsair.doi.dedup.....254f54c65c4b5e88b0176d321ea2b565 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14779137 00219533 |
|---|