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Cost-effectiveness of newborn screening for cystic fibrosis determined with real-life data

التفاصيل البيبلوغرافية
العنوان: Cost-effectiveness of newborn screening for cystic fibrosis determined with real-life data
المؤلفون: van der Ploeg, C. P B, van den Akker-van Marle, M. E., Vernooij-van Langen, A. M M, Elvers, L. H., Gille, J. J P, Verkerk, P. H., Dankert-Roelse, J. E., Loeber, J. G., Triepels, R. H., Van der Ploeg, C. P B, van der Pal, S. M., Dompeling, E., Pals, G., van den Akker van Marle, M. E., Gulmans, V. A M, Oey-Spauwen, M. J W, Wijnands, Y. H H M, Castricum, L. M., Arets, H. G M, van der Ent, C. K., Tiddens, H. A W M, de Rijke, Y. B., Yntema, J. B.
المساهمون: Kindergeneeskunde, RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - R5 - Optimising Patient Care, Public Health, Human genetics, CCA - Disease profiling
المصدر: Journal of Cystic Fibrosis, 14(2), 194-202
van der Ploeg, C P B, van den Akker-v Marie, ME, Vernooij-van Langen, A M M, Elvers, L H, Gille, J J P, Verkerk, P H & Dankert-Roelse, J E 2015, ' Cost-effectiveness of newborn screening for cystic fibrosis determined with real-life data ', Journal of Cystic Fibrosis, vol. 14, no. 2, pp. 194-202 . https://doi.org/10.1016/j.jcf.2014.08.007
Journal of Cystic Fibrosis, 14(2), 194. Elsevier
Journal of Cystic Fibrosis, 14(2), 194-202. Elsevier Science
Journal of Cystic Fibrosis, 14(2), 194-202. Elsevier
سنة النشر: 2015
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Newborn screening, Pediatrics, medicine.medical_specialty, Cost effectiveness, Genetic counseling, Cost-Benefit Analysis, Cystic Fibrosis Transmembrane Conductance Regulator, Pancreatitis-Associated Proteins, Research Support, Sensitivity and Specificity, behavioral disciplines and activities, Cystic fibrosis, Decision Support Techniques, Neonatal Screening, SDG 3 - Good Health and Well-being, Antigens, Neoplasm, medicine, Biomarkers, Tumor, Journal Article, Humans, Lectins, C-Type, Comparative Study, Genetic Testing, Pediatrics, Perinatology, and Child Health, Non-U.S. Gov't, Sweat test, Netherlands, medicine.diagnostic_test, business.industry, Public health, Research Support, Non-U.S. Gov't, Infant, Newborn, Cost-effectiveness analysis, Perinatology, Quality-adjusted life year, and Child Health, Pediatrics, Perinatology and Child Health, Mutation, Trypsinogen, Cost-effectiveness, business, Decision analysis
الوصف: Background: Previous cost-effectiveness studies using data from the literature showed that newborn screening for cystic fibrosis (NBSCF) is a good economic option with positive health effects and longer survival. Methods: We used primary data to compare cost-effectiveness of four screening strategies for NBSCF, i.e. immunoreactive trypsinogen-testing followed by pancreatitis-associated protein-testing (IRT-PAP), IRT-DNA, IRT-DNA sequencing, and IRT-PAP-DNA sequencing, each compared to no-screening. A previously developed decision analysis model for NBSCF was fed with model parameters mainly based on a study evaluating two novel screening strategies among 145,499 newborns in The Netherlands. Results: The four screening strategies had cost-effectiveness ratios varying from sic23,600 to sic29,200 per life-year gained. IRT PAP had the most favourable cost-effectiveness ratio. Additional life-years can be gained by IRT DNA but against higher costs. When treatment costs reduce with 5% due to early diagnosis, screening will lead to financial savings. Conclusion: NBSCF is as an economically justifiable public health initiative. Of the four strategies tested IRT PAP is the most economic and this finding should be included in any decision making model, when considering implementation of newborn screening for CF. (C) 2014 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
وصف الملف: image/pdf
اللغة: English
تدمد: 1569-1993
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cbac0fa3ee8eb5c4763af31dde60ea
http://hdl.handle.net/1887/108027
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....25cbac0fa3ee8eb5c4763af31dde60ea
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15691993