The effect of tranexamic acid in traumatic brain injury: A randomized controlled trial
| العنوان: | The effect of tranexamic acid in traumatic brain injury: A randomized controlled trial |
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| المؤلفون: | Vafa Rahimi-Movaghar, Mahdi Sharif-Alhoseini, Tayyebeh Salehi, Koorosh Ahmadi, Abolfazl Jokar |
| المصدر: | Chinese Journal of Traumatology, Vol 20, Iss 1, Pp 49-51 (2017) Chinese Journal of Traumatology |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Traumatic, Tranexamic acid, Traumatic brain injury, Intracranial hemorrhage, law.invention, Traumatic brain injuries, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Antifibrinolytic agent, Brain Injuries, Traumatic, Cerebral Hemorrhage, Traumatic, medicine, Coagulopathy, Humans, Single-Blind Method, Orthopedics and Sports Medicine, cardiovascular diseases, Cause of death, lcsh:R5-920, business.industry, Mortality rate, 030208 emergency & critical care medicine, Middle Aged, medicine.disease, Antifibrinolytic Agents, nervous system diseases, Increasing risk, Anesthesia, Original Article, Female, Surgery, Tomography, X-Ray Computed, business, lcsh:Medicine (General), 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Purpose: Traumatic brain injury (TBI) is a leading cause of death and disability. Intracranial hemorrhage (ICH) secondary to TBI is associated with a high risk of coagulopathy which leads to increasing risk of hemorrhage growth and higher mortality rate. Therefore, antifibrinolytic agents such as tranexamic acid (TA) might reduce traumatic ICH. The aim of the present study was to investigate the extent of ICH growth after TA administration in TBI patients. Methods: This single-blind randomized controlled trial was conducted on patients with traumatic ICH (with less than 30 ml) referring to the emergency department of Vali-Asr Hospital, Arak, Iran in 2014. Patients, based on the inclusion and exclusion criteria, were divided into intervention and control groups (40 patients each). All patients received a conservative treatment for ICH, as well as either intravenous TA or placebo. The extent of ICH growth as the primary outcome was measured by brain CT scan after 48 h. Results: Although brain CT scan showed a significant increase in hemorrhage volume in both groups after 48 h, it was significantly less in the TA group than in the control group (p = 0.04). The mean total hemorrhage expansion was (1.7 ± 9.7) ml and (4.3 ± 12.9) ml in TA and placebo groups, respectively (p |
| اللغة: | English |
| تدمد: | 1008-1275 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d1827739c6d38efb93a0ef59552338 http://www.sciencedirect.com/science/article/pii/S1008127517300147 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....25d1827739c6d38efb93a0ef59552338 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10081275 |
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