In vitro profiling of the potential endocrine disrupting activities affecting steroid and aryl hydrocarbon receptors of compounds and mixtures prevalent in human drinking water resources
| العنوان: | In vitro profiling of the potential endocrine disrupting activities affecting steroid and aryl hydrocarbon receptors of compounds and mixtures prevalent in human drinking water resources |
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| المؤلفون: | Doan Tq, Marc Muller, Scippo Ml, Lisa Connolly, Nott K, Ahmed Igout |
| المصدر: | Chemosphere Connolly, L 2020, ' In vitro profiling of the potential endocrine disrupting activities affecting steroid and aryl hydrocarbon receptors of compounds and mixtures prevalent in human drinking water resources ', Chemosphere, vol. 258 . https://doi.org/10.1016/j.chemosphere.2020.127332 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Bisphenol A, Environmental Engineering, Polychlorinated Dibenzodioxins, Bisphenol, Health, Toxicology and Mutagenesis, 0208 environmental biotechnology, 02 engineering and technology, 010501 environmental sciences, Endocrine Disruptors, 01 natural sciences, chemistry.chemical_compound, Transactivation, SDG 3 - Good Health and Well-being, Phenols, Genes, Reporter, Basic Helix-Loop-Helix Transcription Factors, Benzo(a)pyrene, Environmental Chemistry, Animals, Humans, Benzhydryl Compounds, Pesticides, Polycyclic Aromatic Hydrocarbons, Receptor, 0105 earth and related environmental sciences, Fluoranthene, biology, Drinking Water, Public Health, Environmental and Occupational Health, Estrogens, General Medicine, General Chemistry, Aryl hydrocarbon receptor, Pollution, 6. Clean water, 3. Good health, 020801 environmental engineering, Rats, chemistry, Biochemistry, Receptors, Aryl Hydrocarbon, 13. Climate action, biology.protein, Water Resources, Pyrene, Water Pollutants, Chemical |
| الوصف: | Prioritizing chemicals posing threats to drinking water resources is crucial for legislation considering the cost of water treatment, remediation, and monitoring. We profiled in vitro potential endocrine disrupting activities (both agonistic and antagonistic) of 18 contaminants most prevalent in Walloon raw water resources intended for drinking water production, including several compound groups: pesticides, perfluorinated compounds, polycyclic aromatic hydrocarbons, a corrosion inhibitor, and bisphenol A. Mixtures thereof relevant for human realistic exposure were also investigated. Seven luciferase reporter gene cell lines were used i.e. three (human and rat) responsive to dioxins through the aryl hydrocarbon receptor (AhR) and four (human) responsive to steroids through the estrogen (ER), androgen (AR), progesterone (PR), and glucocorticoid (GR) receptors. Among the 18 compounds, ten caused at least one response in at least one receptor. Specifically, chlorpyrifos, bisphenol A, fluoranthene, phenanthrene, and benzo [a]pyrene displayed significant activities on several receptors. Bisphenol A agonized ER, but abolished the cells’ response to androgen and progesterone. While fluoranthene and phenanthrene strongly reduced human AhR and AR transactivation, benzo [a]pyrene strongly activated AhR and ER, but inhibited GR and AR. In human breast cancer cells, benzo [a]pyrene dramatically activated AhR, inducing a 10-fold higher response than 2,3,7,8-tetrachlorodibenzodioxin (TCDD) at concentrations possibly found realistically in human blood. The mixture of the 18 compounds exerted both ER and rat AhR agonism, with the main contribution being from benzo [a]pyrene or its combination with bisphenol A. Moreover, the mixture significantly inhibited TCDD-induced CYP1A activity (detected only by EROD assays) in human hepatoma cells. |
| وصف الملف: | application/pdf |
| تدمد: | 1879-1298 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d3faa75d4e948fd20d7809daf95938 https://pubmed.ncbi.nlm.nih.gov/32554009 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....25d3faa75d4e948fd20d7809daf95938 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18791298 |
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