Placentas delivered by pre‐pregnant obese women have reduced abundance and diversity in the microbiome
| العنوان: | Placentas delivered by pre‐pregnant obese women have reduced abundance and diversity in the microbiome |
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| المؤلفون: | Fadhl M. Al-Akwaa, Corbin Dirkx, Ingrid Chern, Ryan Schlueter, Dan Knights, Susan L Hoops, Lana X. Garmire, Thomas K. Wolfgruber, Paula Benny |
| المصدر: | The FASEB Journal |
| بيانات النشر: | John Wiley and Sons Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Placenta, Physiology, Biology, Biochemistry, 16S sequencing, Cohort Studies, Fetal Development, Obesity, Maternal, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Genetics, medicine, Humans, Microbiome, Obesity, Molecular Biology, reproductive and urinary physiology, Research Articles, Fetus, Microbiota, Fetal health, medicine.disease, Pregnancy Complications, 030104 developmental biology, medicine.anatomical_structure, Cohort, embryonic structures, Female, 030217 neurology & neurosurgery, Biotechnology, Research Article |
| الوصف: | Maternal pre‐pregnancy obesity may have an impact on both maternal and fetal health. We examined the microbiome recovered from placentas in a multi‐ethnic maternal pre‐pregnant obesity cohort, through an optimized microbiome protocol to enrich low bacterial biomass samples. We found that the microbiomes recovered from the placentas of obese pre‐pregnant mothers are less abundant and less diverse when compared to those from mothers of normal pre‐pregnancy weight. Microbiome richness also decreases from the maternal side to the fetal side, demonstrating heterogeneity by geolocation within the placenta. In summary, our study shows that the microbiomes recovered from the placentas are associated with pre‐pregnancy obesity. Importance Maternal pre‐pregnancy obesity may have an impact on both maternal and fetal health. The placenta is an important organ at the interface of the mother and fetus, and supplies nutrients to the fetus. We report that the microbiomes enriched from the placentas of obese pre‐pregnant mothers are less abundant and less diverse when compared to those from mothers of normal pre‐pregnancy weight. More over, the microbiomes also vary by geolocation within the placenta. |
| اللغة: | English |
| تدمد: | 1530-6860 0892-6638 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25de4709c11f8faf440e4f113ac49085 http://europepmc.org/articles/PMC8251846 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....25de4709c11f8faf440e4f113ac49085 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15306860 08926638 |
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