A beat-by-beat, on-line, cardiovascular index, CARDEAN, to assess circulatory responses to surgery: a randomized clinical trial during spine surgery
| العنوان: | A beat-by-beat, on-line, cardiovascular index, CARDEAN, to assess circulatory responses to surgery: a randomized clinical trial during spine surgery |
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| المؤلفون: | J. Carcey, C. Halle, M. Gardellin, Jean-François Payen, M. E. Oddoux, Luc Quintin, M. C. Fevre, A. Cividjian, M. Frost, Mauro Rossi |
| المصدر: | Journal of Clinical Monitoring and Computing. 26:441-449 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Nociception, Tachycardia, medicine.medical_specialty, Remifentanil, Hemodynamics, Blood Pressure, Health Informatics, Critical Care and Intensive Care Medicine, law.invention, Piperidines, Randomized controlled trial, Heart Rate, law, Monitoring, Intraoperative, Heart rate, medicine, Humans, Single-Blind Method, Intervertebral Disc, Propofol, business.industry, Baroreflex, Middle Aged, Surgery, Analgesics, Opioid, Anesthesiology and Pain Medicine, Blood pressure, Bispectral index, Anesthesia, Female, medicine.symptom, business, Anesthetics, Intravenous, medicine.drug |
| الوصف: | Automated assessment of circulatory response to surgical stimuli is unsolved. Would detection of cardiac baroreflex inhibition assess adequacy of intra-operative anti-nociception upon incision, as performed on-line on a beat-by-beat basis by a cardiovascular index, CARDEAN™? 18 ASA I-II patients undergoing spinal disc repair were studied, in a prospective randomized single-blinded trial (observational study). During infusion of propofol to maintain bispectral index between 40 and 60, patients were allocated to receive an effect site target-controlled infusion of remifentanil at Ce = 2 or 4 ng ml(-1). Upon incision and during surgery, circulatory response was assessed using beat-by-beat measurements of minor hypertension and tachycardia to give a cardiovascular index, CARDEAN, scaled between 0 and 100. Upon skin incision, CARDEAN increased in the remifentanil Ce = 2 ng ml(-1) group (n = 7, P0.05), while it did not increase in the remifentanil Ce = 4 ng ml(-1) group (n = 7, P = 0.18). During surgery, retrospectively, CARDEAN60 was associated with tachycardia and hypertension (P (k) = 0.81 ± 0.10). Changes in CARDEAN appeared linked to adequacy of anti-nociception. |
| تدمد: | 1573-2614 1387-1307 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26466ad9d9ade103ebeda6b3915038f7 https://doi.org/10.1007/s10877-012-9372-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....26466ad9d9ade103ebeda6b3915038f7 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15732614 13871307 |
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