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Complementary Serologic Investigations in Children with Celiac Disease Is Unnecessary during Follow-Up

التفاصيل البيبلوغرافية
العنوان: Complementary Serologic Investigations in Children with Celiac Disease Is Unnecessary during Follow-Up
المؤلفون: Margaretha M. S. Wessels, M. L. Mearin, Hein Putter, Sabine L. Vriezinga, Edmond H. H. M. Rings, Iris I. van Veen
المساهمون: Pediatrics
المصدر: Journal of Pediatrics, 169, 55-60
Journal of Pediatrics, 169, 55-60. Mosby Inc.
سنة النشر: 2016
مصطلحات موضوعية: Male, medicine.medical_specialty, Adolescent, Unnecessary Procedures, Gastroenterology, vitamin D deficiency, 03 medical and health sciences, Diet, Gluten-Free, 0302 clinical medicine, Internal medicine, medicine, Vitamin D and neurology, Humans, 030212 general & internal medicine, Vitamin B12, Child, Retrospective Studies, Hematologic Tests, biology, business.industry, Thyroid disease, Malnutrition, Iron deficiency, medicine.disease, Thyroid Diseases, Ferritin, Celiac Disease, Endocrinology, Iron-deficiency anemia, Pediatrics, Perinatology and Child Health, biology.protein, 030211 gastroenterology & hepatology, Female, Thyroid function, business, Follow-Up Studies
الوصف: Objectives To determine the frequency of nutritional deficiencies and thyroid dysfunction in children with celiac disease (CD) and during follow-up after initiation of a gluten-free diet. Laboratory investigations of hemoglobin, ferritin, calcium, folate, vitamin B12, vitamin D, and thyroid function are regularly ordered in children with CD despite sufficient evidence for these. Study design Between 2009 and 2014, test results of hemoglobin, ferritin, folate, vitamin B12, calcium, vitamin D (25[OH]D), free thyroxin, and thyroid stimulating hormone of children with CD regularly seen at the Leiden University Medical Center were investigated. Laboratory reference ranges were used to define abnormal results. Pearson χ2 test for trend, unpaired t test, and 1-way ANOVA were used for statistical analysis. Results Of the 182 children evaluated, 119 were newly diagnosed. On average, 17% of results per year were missing because of incomplete blood investigations. Iron deficiency (28%) and iron deficiency anemia (9%) were found at the time of diagnosis of CD. Folate (14%), vitamin B12 (1%), and vitamin D deficiencies (27%) were also seen. No hypocalcemia or thyroid dysfunction was found. At follow-up, iron deficiency, iron deficiency anemia, and folate and vitamin D deficiency were observed in 8%, 2%, 3%, and 25% of patients, respectively. Vitamin B12 deficiency, hypocalcemia, and thyroid disease were not found. Conclusions Complementary blood investigations are relevant at the time of diagnosis of CD but have little diagnostic yield during follow-up visits once the patient is placed on a gluten-free diet. Thus, we recommend that these variables only be assessed on indication, such as fatigue or abnormal growth.
اللغة: English
تدمد: 0022-3476
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2653787b49c067b2487510f007cd313d
https://doi.org/10.1016/j.jpeds.2015.09.078
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....2653787b49c067b2487510f007cd313d
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00223476