Placental pathology and outcome after perinatal asphyxia and therapeutic hypothermia
| العنوان: | Placental pathology and outcome after perinatal asphyxia and therapeutic hypothermia |
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| المؤلفون: | L S de Vries, I. C. van Haastert, Floris Groenendaal, C M C Frank, Corine Koopman-Esseboom, Mjnl Benders, Johanna C. Harteman, Peter G. J. Nikkels |
| المصدر: | Journal of Perinatology. 36:977-984 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Pediatrics, Placenta, Population, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Hypothermia, Induced, Pregnancy, 030225 pediatrics, Severity of illness, medicine, Humans, Neonatology, education, Retrospective Studies, Asphyxia Neonatorum, education.field_of_study, business.industry, Obstetrics, Infant, Newborn, Obstetrics and Gynecology, Gestational age, Retrospective cohort study, Hypothermia, medicine.disease, Magnetic Resonance Imaging, Perinatal asphyxia, Treatment Outcome, Brain Injuries, Multivariate Analysis, Pediatrics, Perinatology and Child Health, Apgar Score, Female, Apgar score, medicine.symptom, business, 030217 neurology & neurosurgery |
| الوصف: | Objective To assess the relationship between placental pathology, pattern of brain injury and neurodevelopmental outcome in term infants with perinatal asphyxia receiving therapeutic hypothermia. Study design Studies were performed in 76 infants. Death or survival with impairments at 18 to 24 months was used as a composite adverse outcome. Multivariable analysis was performed. Results Among the 75 infants analyzed, the predominant pattern of brain injury was: no injury (n=27), a white matter/watershed pattern (n=14), basal-ganglia-thalamic injury (n=13) or near-total brain injury (n=21). An adverse outcome was seen in 35 of the 76 infants. Elevated nucleated red blood cells were associated with white matter involvement. Small placental infarcts were more common among infants without brain injury. All other placental abnormalities were not related to both outcome measures. Conclusion In our population of term infants receiving therapeutic hypothermia, no type of placental pathology was related to extensive brain injury or adverse neurodevelopmental outcome. |
| تدمد: | 1476-5543 0743-8346 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265fa76f15c0a710bee029f6f33346d7 https://doi.org/10.1038/jp.2016.110 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....265fa76f15c0a710bee029f6f33346d7 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14765543 07438346 |
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