Increased day-to-day fluctuations in exhaled breath profiles after a rhinovirus challenge in asthma
| العنوان: | Increased day-to-day fluctuations in exhaled breath profiles after a rhinovirus challenge in asthma |
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| المؤلفون: | Yennece W.F. Dagelet, Susanne J. H. Vijverberg, Binbin Xu, Anke H. Maitland-van der Zee, Louwrina H Te Nijenhuis, Erik Duijvelaar, Ariana Lammers, René Lutter, Anirban Sinha, Rianne de Vries, Anne H. Neerincx, Peter J. Sterk, Mahmoud I. Abdel-Aziz, Paul Brinkman, Urs Frey |
| المساهمون: | Graduate School, AII - Inflammatory diseases, APH - Personalized Medicine, Pulmonology, ARD - Amsterdam Reproduction and Development, University of Amsterdam [Amsterdam] (UvA), Breathomix, EuroMov - Digital Health in Motion (Euromov DHM), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Montpellier (UM), University of Basel (Unibas) |
| المصدر: | Allergy: European Journal of Allergy and Clinical Immunology, 76(8), 2488-2499. Wiley-Blackwell Allergy Allergy, Wiley, 2021, 76 (8), pp.Pages 2488-2499. ⟨10.1111/all.14811⟩ |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Rhinovirus, Immunology, Early detection, virus, Asthma and Lower Airway Disease, Nitric Oxide, medicine.disease_cause, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Internal medicine, Humans, Immunology and Allergy, Medicine, omics and systems biology, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, Electronic Nose, 030304 developmental biology, Asthma, 0303 health sciences, Receiver operating characteristic, business.industry, biomarkers, asthma, medicine.disease, 3. Good health, Breath Tests, 030228 respiratory system, Breath gas analysis, Exhalation, Exhaled nitric oxide, Original Article, ORIGINAL ARTICLES, Day to day, business, Area under the roc curve |
| الوصف: | Background Early detection/prediction of flare‐ups in asthma, commonly triggered by viruses, would enable timely treatment. Previous studies on exhaled breath analysis by electronic nose (eNose) technology could discriminate between stable and unstable episodes of asthma, using single/few time‐points. To investigate its monitoring properties during these episodes, we examined day‐to‐day fluctuations in exhaled breath profiles, before and after a rhinovirus‐16 (RV16) challenge, in healthy and asthmatic adults. Methods In this proof‐of‐concept study, 12 atopic asthmatic and 12 non‐atopic healthy adults were prospectively followed thrice weekly, 60 days before, and 30 days after a RV16 challenge. Exhaled breath profiles were detected using an eNose, consisting of 7 different sensors. Per sensor, individual means were calculated using pre‐challenge visits. Absolute deviations (|%|) from this baseline were derived for all visits. Within‐group comparisons were tested with Mann‐Whitney U tests and receiver operating characteristic (ROC) analysis. Finally, Spearman's correlations between the total change in eNose deviations and fractional exhaled nitric oxide (FeNO), cold‐like symptoms, and pro‐inflammatory cytokines were examined. Results Both groups had significantly increased eNose fluctuations post‐challenge, which in asthma started 1 day post‐challenge, before the onset of symptoms. Discrimination between pre‐ and post‐challenge reached an area under the ROC curve of 0.82 (95% CI = 0.65–0.99) in healthy and 0.97 (95% CI = 0.91–1.00) in asthmatic adults. The total change in eNose deviations moderately correlated with IL‐8 and TNFα (ρ ≈ .50–0.60) in asthmatics. Conclusion Electronic nose fluctuations rapidly increase after a RV16 challenge, with distinct differences between healthy and asthmatic adults, suggesting that this technology could be useful in monitoring virus‐driven unstable episodes in asthma. Electronic nose sensor fluctuations increased after a RV‐16 challenge in asthmatic and healthy adults, more evidently in asthma. In asthma, the increase in eNose fluctuations occurred before the onset of cold‐like symptoms. The magnitude of the change in eNose fluctuations was not correlated with FeNO and cold‐like symptoms, but moderately correlated with pre‐ and post‐challenge cytokine levels in asthma. |
| اللغة: | English |
| تدمد: | 0105-4538 1398-9995 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f9bcc637b1d7e4acc68c36225ecc69 https://pure.amc.nl/en/publications/increased-daytoday-fluctuations-in-exhaled-breath-profiles-after-a-rhinovirus-challenge-in-asthma(19eb7fd0-d4f6-45ee-bb11-3285cf7eb3b4).html |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....26f9bcc637b1d7e4acc68c36225ecc69 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01054538 13989995 |
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