Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review
| العنوان: | Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review |
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| المؤلفون: | Maria Antonietta Clemente, Michele Piombino, Arcangela Raguso, Elisa Donno, Federico Parisi, Gerardo Sanpaolo, Sabrina Cossa, Guido Valle, Pietro Corsa, Antonio Perrone, Salvatore Parisi, Tindara Munafò |
| المصدر: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| بيانات النشر: | Hindawi Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Oncology, medicine.medical_specialty, Article Subject, Dacarbazine, medicine.medical_treatment, lcsh:Medicine, General Biochemistry, Genetics and Molecular Biology, Glioma, Internal medicine, Temozolomide, medicine, Humans, Combined Modality Therapy, Aged, Retrospective Studies, General Immunology and Microbiology, Brain Neoplasms, business.industry, lcsh:R, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Radiation therapy, Concomitant, Clinical Study, Female, business, Adjuvant, medicine.drug |
| الوصف: | Temozolomide (TMZ) is the first line drug in the care of high grade gliomas. The combined treatment of TMZ plus radiotherapy is more effective in the care of brain gliomas then radiotherapy alone. Aim of this report is a survival comparison, on a long time (>10 years) span, of glioma patients treated with radiotherapy alone and with radiotherapy + TMZ.Materials and Methods. In this report we retrospectively reviewed the outcome of 128 consecutive pts with diagnosis of high grade gliomas referred to our institutions from April 1994 to November 2001. The first 64 pts were treated with RT alone and the other 64 with a combination of RT and adjuvant or concomitant TMZ.Results. Grade 3 (G3) haematological toxicity was recorded in 6 (9%) of 64 pts treated with RT and TMZ. No G4 haematological toxicity was observed. Age, histology, and administration of TMZ were statistically significant prognostic factors associated with 2 years overall survival (OS). PFS was for GBM 9 months, for AA 11.Conclusions. The combination of RT and TMZ improves long term survival in glioma patients. Our results confirm the superiority of the combination on a long time basis. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2314-6141 2314-6133 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2732e435f9dc65f25fcab32be4824b03 https://doaj.org/article/76d81da99c6348c29e25763c3b994ed6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2732e435f9dc65f25fcab32be4824b03 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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