Transforming sustained release into on-demand release: self-healing guanosine–borate supramolecular hydrogels with multiple responsiveness for Acyclovir delivery
| العنوان: | Transforming sustained release into on-demand release: self-healing guanosine–borate supramolecular hydrogels with multiple responsiveness for Acyclovir delivery |
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| المؤلفون: | Yunfeng Shi, Wei Xue, Cheng-Guang Wu, Yi Zhang, Xiang Wang, Bin-cheng Wang |
| المصدر: | Biomaterials Science. 8:6190-6203 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Guanosine, Biocompatibility, Biomolecule, Kinetics, technology, industry, and agriculture, Biomedical Engineering, Supramolecular chemistry, Acyclovir, Hydrogels, macromolecular substances, complex mixtures, chemistry.chemical_compound, chemistry, Chemical engineering, Delayed-Action Preparations, Borates, Self-healing hydrogels, Drug delivery, General Materials Science, Nucleoside |
| الوصف: | Supramolecular hydrogels derived from natural biomolecules have promising applications for drug delivery due to their inherent biocompatibility and tunable responsiveness to various stimuli. However, conventional hydrogels only modulate the release kinetics roughly to achieve sustained drug release, exhibiting fast-then-slow release behavior without on/off control. Herein, a guanosine (G)-quartet·Na+-borate supramolecular hydrogel (GB hydrogel) cross-linked via a guanosine-borate diester and intertwined by G4-nanofibres formed by π-π stacking of G4-quartets stabilized by Na+ is developed for on-demand release of Acyclovir (Acv). This GB hydrogel is facilely prepared by a one-pot hierarchical assembly involving hydrogen bonds, dynamic borate ester bonds and cation coordination, which endow it with tunable mechanical properties, excellent self-healing properties and reversible degradation behavior in response to pH, glucose and ion concentration. Benefiting from that the guanosine analog Acv is able to assemble into a G4-quartet by replacing guanosine via reversible hydrogen bonding, the Acv-loaded GB hydrogel showed favorable stability in physiological medium without undesired release and achieved external stimulus-triggered on-demand release with switchable on/off control and tunable release kinetics. Moreover, the GB hydrogel also exhibited excellent in vitro and in vivo biocompatibility. Such a natural nucleoside-based supramolecular hydrogel with on-demand drug release, self-healing property, biodegradability and biocompatibility provides a precisely controlled paradigm to overcome early burst release behavior of conventional hydrogels for the development of injectable hydrogel delivery systems. |
| تدمد: | 2047-4849 2047-4830 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274e86c34ffc36d5885f99706e48a8a6 https://doi.org/10.1039/d0bm00966k |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....274e86c34ffc36d5885f99706e48a8a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20474849 20474830 |
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