Alteration in gene expression profiles of thymoma: Genetic differences and potential novel targets
| العنوان: | Alteration in gene expression profiles of thymoma: Genetic differences and potential novel targets |
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| المؤلفون: | Yi Jie Yan, Chun Yang Wang, Fan Jie Meng, Chang Li Wang, Jun Zhang, Shuo Wang, Chun Rui Yang, Zhi Yu Guan |
| المصدر: | Thoracic Cancer |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Pulmonary and Respiratory Medicine, Candidate gene, Thymoma, Microarray, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Gene expression, Biomarkers, Tumor, Humans, Medicine, Gene, Messenger RNA, messenger RNA, business.industry, Gene Expression Profiling, Computational Biology, Original Articles, General Medicine, medicine.disease, pathway analysis, Calcium activated phosphatidylcholine scrambling, Gene Expression Regulation, Neoplastic, Gene Ontology, 030104 developmental biology, Mediastinal Cyst, Oncology, Case-Control Studies, 030220 oncology & carcinogenesis, Cancer research, Female, Original Article, Transcriptome, business, microarray |
| الوصف: | Background This study was conducted to investigate the gene expression profiles associated with thymoma to better understand the molecular mechanism underlying the pathogenesis of thymoma. Methods Eight patients with thymomas (type A, AB, B1, and B2) and four controls with thymic cysts were analyzed using microarray profiling to identify changes in gene expression. Results Across all of our samples, 2319 messenger RNAs were upregulated and 2776 were downregulated in thymomas relative to thymic cysts. Gene ontology and pathway analyses revealed that a large number of genes participate in cellular functions, among which MHC class II protein complex assembly, assembly with peptide antigen, calcium activated phosphatidylcholine scrambling, and release of cytoplasmic sequestered NF-κB were dysregulated, whereas intestinal immune network for immunoglobulin A production, cytokine-cytokine receptor interaction, the calcium signaling pathway, and pathways related to autoimmune diseases were downregulated. Conclusions Our results revealed gene expression differences between thymomas and thymic cysts, and identified key candidate genes/pathways that might be used as diagnostic markers and potential therapeutic targets to treat cancer metastasis. |
| تدمد: | 1759-7714 1759-7706 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2768b32aad532994590f3763c680c35c https://doi.org/10.1111/1759-7714.13053 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2768b32aad532994590f3763c680c35c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17597714 17597706 |
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