Repeated onabotulinum neurotoxin A injections for drooling in children with neurodisability
| العنوان: | Repeated onabotulinum neurotoxin A injections for drooling in children with neurodisability |
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| المؤلفون: | Arthur R T Scheffer, Theresa Ys Leow, Frank J. A. van den Hoogen, Stijn Bekkers, Karen van Hulst, Lynn B Orriëns |
| المصدر: | Developmental Medicine and Child Neurology Developmental Medicine & Child Neurology, 63, 991-997 Developmental Medicine & Child Neurology, 63, 8, pp. 991-997 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 030506 rehabilitation, Adolescent, Subjective effects, Visual analogue scale, Drooling, Cerebral palsy, 03 medical and health sciences, 0302 clinical medicine, Developmental Neuroscience, medicine, Neurodisability, Humans, Neurotoxin, Botulinum Toxins, Type A, Child, business.industry, Cerebral Palsy, Retrospective cohort study, Sialorrhea, Original Articles, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], medicine.disease, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Treatment Outcome, Neuromuscular Agents, Child, Preschool, Anesthesia, Pediatrics, Perinatology and Child Health, Female, Original Article, Neurology (clinical), medicine.symptom, 0305 other medical science, business, 030217 neurology & neurosurgery, After treatment, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] |
| الوصف: | Aim To evaluate the effect of repeated onabotulinum neurotoxin A injections for the treatment of drooling in children with neurodisabilities. Method This was a retrospective cohort study, in which the first, second, and third onabotulinum neurotoxin A injection were compared within children treated between 2000 and 2020. Primary outcomes included drooling quotient, visual analogue scale (VAS), and treatment success defined as ≥50% reduction in drooling quotient and/or VAS 8 weeks after treatment. Each outcome was obtained at baseline and 8 weeks posttreatment. Results Seventy‐seven children were included (mean age at first injection: 8y 3mo, SD 3y 7mo, range 3–17y; 44 males, 33 females; 51.9% with cerebral palsy, 45.5% wheelchair‐bound). The objective (drooling quotient) and subjective (VAS) effect after the second injection was lower compared to the first injection. The third injection showed less objective and significantly less subjective effect compared to the first injection. An overall success rate of 74.0%, 41.6%, and 45.8% were found for the first, second, and third injection respectively. Interpretation Although onabotulinum neurotoxin A remained effective throughout the entire treatment course, there is less effect of subsequent onabotulinum neurotoxin A injections compared to the first. Although there might be a loss of effect after repeated injections, there is continued improvement for most children. What this paper adds Repeated injections show a diminished treatment effect after the second injection.A continued improvement is seen in most patients. What this paper adds Repeated injections show a diminished treatment effect after the second injection.A continued improvement is seen in most patients. This article's abstract has been translated into Spanish and Portuguese. Follow the links from the abstract to view the translations. |
| وصف الملف: | application/pdf |
| تدمد: | 1469-8749 0012-1622 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276b3dbec59e14d668905a04cfc363e5 https://doi.org/10.1111/dmcn.14872 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....276b3dbec59e14d668905a04cfc363e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14698749 00121622 |
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